Figure 5. Intranasal administration of ICZ liquid solution prevents HRV infection.

Mice were intranasally administered with ICZ liquid solution (ICZ Soln) 1 day before intranasal infection with HRV; 8 h post-infection, lung tissue was homogenized and the supernatant was used for analysis. (A) Relative HRV gene expression levels. ^∗∗P < 0.01 (t test). (B–F) Cytokine and chemokine levels. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001, Newman-Keuls multiple comparisons test (analysis of variance).