Table 2.
Baseline Characteristics by Groupa
| Neither (n=1439) | Only e4 (n=324) | Only Dep (n=146) | Both (n=23) | P Valueb | |
|---|---|---|---|---|---|
| Age at baseline, examination 4, mean (SD), y | 76.3 (3.6) | 76.1 (3.6) | 76.2 (3.2) | 75.7 (2.2) | .37 |
| Education >6 y, % | 97.8 | 97.5 | 97.1 | 96.7 | .27 |
| Midlife BP, mean (SD), mm Hg | |||||
| Systolic | 129.8 (15.2) | 130.2 (9.0) | 130.7 (10.9) | 131.2 (7.2) | .27 |
| Diastolic | 82.3 (7.6) | 82.7 (5.4) | 83.0 (7.2) | 83.4 (4.3) | .25 |
| Body mass index, mean (SD)c | 23.9 (3.8) | 23.8 (1.8) | 23.6 (2.4) | 23.5 (1.4) | .28 |
| Diabetes mellitus, % | 34.5 | 34.3 | 34.2 | 34.1 | .77 |
| Total cholesterol, mean (SD), mg/dL | 193.3 (30.3) | 193.2 (18.0) | 193.1 (23.0) | 193.0 (14.4) | .44 |
| Never smoked, % | 36.7 | 38.4 | 40.1 | 41.9 | .34 |
| Ankle-brachial index <0.9, % | 6.3 | 8.2 | 10.7 | 13.9 | .03 |
| Stroke, % | 6.4 | 7.8 | 9.3 | 11.1 | .54 |
| Dementia incidence, % | 4.2 | 6.3 | 9.3 | 13.7 | .004 |
Abbreviation: BP, blood pressure.
SI conversion factor: To convert cholesterol to millimoles per liter, multiply by 0.0259.
a
Neither refers to men without depressive symptoms and apolipoprotein E ε4 (APOE ε4) negative; only e4, men without depressive symptoms and APOE ε4 positive; only Dep, men with depressive symptoms and APOE ε4 negative; and both, men with depressive symptoms and APOE ε4 positive.
b
P values are from linear (continuous variables) and logistic (categorical variables) regression models for 3 groups (neither, single [combined only e4 and only Dep], and both) and are adjusted for age at baseline.
c
Calculated as weight in kilograms divided by height in meters squared.