Table 3.

Data for Dementia in Men With Depressive Symptoms

	Standard Modela,b	Extended Modela,b
All dementiad	2.5 (1.5–4.1)e	2.2 (1.3–3.7)f
Pure ADd	3.0 (1.5–5.9)f	2.9 (1.4–5.9)f
Vascular dementia	2.2 (0.6–7.4)	1.3 (0.3–5.8)
Mixed ADd	2.9 (1.6–5.2)e	2.8 (1.5–5.1)f

Abbreviations: mixed AD, all Alzheimer disease including those with cerebrovascular disease; pure AD, Alzheimer disease without apparent cerebrovascular disease.

^aData are given as hazard ratio (95% confidence interval). The reference group was nondepressed men.

^bAdjusted for age at examination 4, educational level, and self-reported memory deterioration at baseline.

^cAdjusted for age at examination 4, educational level, self-reported memory deterioration at baseline, midlife systolic and diastolic blood pressure, diabetes mellitus, smoking status, cholesterol level at examination 4, body mass index at examination 4, and stroke history.

^dThe interaction term (depression × apolipoprotein E ε4) is significant in the standard and extended models (P<.01 for both).

^eP<.001.

^fP<.01.