Table 4.

Data for Incident Dementia and Its Subtypes by the Presence of Depressive Symptoms and APOE ε4^a

	Hazard Ratio (95% Confidence Interval)
	Neither	Only e4	Only Dep	Both
All dementia
No. of participants	1439	324	146	23
Standard model	1 [Reference]	1.1 (0.6–1.7)	1.9 (1.1–3.4)b	7.2 (3.1–16.8)c
Extended model	1 [Reference]	1.1 (0.6–1.8)	1.6 (0.8–3.0)	7.1 (3.0–16.7)c
Pure AD
No. of participants	1397	318	140	21
Standard model	1 [Reference]	1.5 (0.7–3.0)	2.3 (1.0–5.3)b	12.6 (4.4–37.0)c
Extended model	1 [Reference]	1.6 (0.8–3.1)	2.2 (0.9–5.2)	13.0 (4.3–39.5)c
Vascular dementia
No. of participants	1382	307	135	18
Standard model	1 [Reference]	NA	1.3 (0.3–5.8)	5.2 (0.7–40.1)
Extended model	1 [Reference]	NA	0.6 (0.1–4.8)	4.1 (0.5–33.7)
Mixed AD
No. of participants	1408	321	142	22
Standard model	1 [Reference]	1.4 (0.8–2.6)	2.3 (1.1–4.7)b	10.7 (4.2–27.3)c
Extended model	1 [Reference]	1.5 (0.8–2.7)	2.1 (0.9–4.5)	10.4 (3.9–27.4)c

Abbreviations: APOE ε4, apolipoprotein E ε4; mixed AD, all Alzheimer disease including those with cerebrovascular disease; NA, not applicable owing to the small number; pure AD, Alzheimer disease without apparent cerebrovascular disease.

^aNeither refers to men without depressive symptoms and APOE ε4 negative; only e4, men without depressive symptoms and APOE ε4 positive; only Dep, men with depressive symptoms and APOE ε4 negative; and both, men with depressive symptoms and APOE ε4 positive. The standard model was adjusted for age at examination 4, educational level, and self-reported memory deterioration at baseline. The extended model was adjusted for age at examination 4, educational level, self-reported memory deterioration at baseline, midlife systolic and diastolic blood pressure, diabetes mellitus, smoking status, cholesterol level at examination 4, body mass index at examination 4, and stroke history.

^bP<.05.

^cP<.001.