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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Neurobiol Aging. 2016 Jan 6;40:22–40. doi: 10.1016/j.neurobiolaging.2015.12.021

Fig. 7.

Fig. 7

df/df/APP/PS1 mice had attenuated Aβ plaque deposition and gliosis in the temporal cortex. Brains were collected from wild type (+/+), APP/PS1, dwarf het (df/+), dwarf het APP/PS1 (df/+/APP/PS1), dwarf (df/df), and dwarf APP/PS1 (df/df/APP/PS1) mice, fixed in 4% paraformaldehyde, serially sectioned, and immunostained. Tissue sections were immunostained using anti-Aβ 4G8 or BAM-10, anti-Iba-1 and anti-GFAP antibodies and antibody binding was visualized using Vector VIP as the chromogen. Representative temporal cortex images from 8-13 mice in each group are shown.