Figure 2.

Effect of soluble TNF–like weak inducer of apoptosis (sTWEAK) on cardiovascular outcomes. (A) Kaplan–Meier curve of cardiovascular mortality risk in patients with CKD according to sTWEAK tertiles. (B) Kaplan–Meier plot of cumulative probability of a first major cardiovascular event when patients with CKD were grouped according to sTWEAK tertiles. Low sTWEAK levels were defined as sTWEAK concentration <33rd percentile (<289 pg/ml), and high sTWEAK levels were defined as its concentration >66th percentile (>465 pg/ml). (C) Receiver–operating characteristic curves for cardiovascular events prediction. Curves are on the basis of logistic regression models incorporating conventional risk variables (age, sex, smoking status, diabetes mellitus, hypertension, hyperlipidemia, and eGFR) with and without sTWEAK.