Table 2.
Bone histomorphometric parameters in patients on dialysis with normal to high bone turnover, pure osteomalacia, and adynamic bone disease and healthy controls
| Parameter | Dialysis: Normal To High Bone Turnover (n=52) | Dialysis: Pure Osteomalacia (n=7) | Dialysis: Adynamic Bone (n=9) | Healthy Controls (n=14) |
|---|---|---|---|---|
| Bone volume (BV/TV), % | 30.1±1.1 | 29.1±3.5 | 28.0±1.0 | 21.4±1.5 |
| Trabecular thickness, μm | 167±5 | 145±15 | 137±13 | 141±14 |
| Trabecular separation, μm | 406±16 | 343±38 | 355±29 | 459±22 |
| Osteoid volume (OV/BV), % | 11.9±0.7 | 28.4±3.9 | 1.1±0.4a | 2.2±0.4 |
| Osteoid surface (OS/BS), % | 47.0±1.8 | 67.2±6.5 | 10.0±2.0a | 16.6±2.7 |
| Osteoid thickness, μm | 19.8±0.6 | 27.8±4.0 | 6.1±0.6a | 8.3±0.8 |
| Bone formation rate (BFR/BS), μm3/μm2 per year | 85.2 (51.7, 133.4) | 0 (0, 7.7) | 0.8 (0, 5.9) | 59.1 (23.0, 64.7) |
BV/TV, bone volume/tissue volume; OV/BV, osteoid volume/bone volume; OS/BS, osteoid surface/bone surface; BFR/BS, bone formation rate/bone surface.
a
P<0.001 between adynamic bone and osteomalacia for OV/BV, OS/BS, and osteoid thickness.