Table 3.
Factors associated with ESRD by immunosuppression status
| Variables | Hazard Ratio | 95% Confidence Interval |
|---|---|---|
| Unadjusted | ||
| Immunosuppression | ||
| None | 1 | |
| CNIs with or without glucocorticoids or glucocorticoids alone | 0.50 | 0.29 to 0.87 |
| Adjusteda | ||
| Immunosuppression | ||
| None | 1 | |
| CNIs with or without glucocorticoids or glucocorticoids alone | 0.49 | 0.28 to 0.86 |
| Age per 1-yr increase | 1.00 | 0.99 to 1.01 |
| Men | 1.15 | 0.76 to 1.73 |
| FSGS variant | ||
| NOS | 1 | |
| Tip | 0.21 | 0.09 to 0.48 |
| Collapsing | 1.71 | 0.99 to 2.95 |
| Baseline eGFR <30 ml/min per 1.73 m2 | 4.28 | 2.81 to 6.48 |
| Baseline proteinuria ≥3.5 g/d | 1.25 | 0.68 to 2.29 |
| Serum albumin at biopsy per 1 g/dl higher | 0.69 | 0.53 to 0.90 |
| Hypertension at baseline | 1.33 | 0.81 to 2.20 |
| Adjusted (adults only)b | ||
| Immunosuppression | ||
| None | 1 | |
| CNIs with or without glucocorticoids or glucocorticoids alone | 0.43 | 0.21 to 0.86 |
CNI, calcineurin inhibitor; NOS, not otherwise specified.
a
Cox regression adjusted for immunosuppression, age, sex, black race, FSGS variant, and baseline eGFR, proteinuria, serum albumin, and hypertension.
b
Cox regression in adult patients only adjusted for immunosuppression, age, sex, black race, FSGS variant, and baseline eGFR, proteinuria, serum albumin, and hypertension.