Table 4.
Factors associated with ESRD among treated patients
| Variables | Hazard Ratio | 95% Confidence Interval |
|---|---|---|
| Unadjusted | ||
| Immunosuppressive therapy | ||
| Glucocorticoids | 1.00 | |
| CNIs with or without glucocorticoids | 0.60 | 0.21 to 1.70 |
| Adjusteda | ||
| Immunosuppressive therapy | ||
| Glucocorticoids | 1.00 | |
| CNIs with or without glucocorticoids | 0.42 | 0.15 to 1.18 |
| Age per 1-yr increase | 1.00 | 0.99 to 1.02 |
| Men | 1.00 | 0.56 to 1.76 |
| FSGS variant | ||
| NOS | 1.00 | |
| Tip | 0.14 | 0.04 to 0.47 |
| Collapsing | 0.98 | 0.48 to 2.00 |
| Baseline eGFR <30 ml/min per 1.73 m2 | 2.61 | 1.37 to 4.96 |
| Serum albumin at biopsy per 1 g/dl higher | 0.55 | 0.39 to 0.78 |
| Adjusted (adults only)b | ||
| Immunosuppressive therapy | ||
| Glucocorticoids | 1.00 | |
| CNIs with or without glucocorticoids | 0.40 | 0.09 to 1.90 |
CNI, calcineurin inhibitor; NOS, not otherwise specified.
a
Cox regression adjusted for immunosuppression, age, sex, black race, FSGS variant, and baseline eGFR and serum albumin; baseline hypertension was not predictive of renal survival by univariate analysis.
b
Cox regression in adult patients only adjusted for immunosuppression, age, FSGS variant, and baseline eGFR and serum albumin.