TABLE 2 .
Submicromolar TbCet1 inhibitors identified via HTS and confirmed by manual assay
| Compound | Name | Class | IC50 (µM) by assay: |
|
|---|---|---|---|---|
| HTS | 32P | |||
| 1A | Tetracaffeoylquinic acid | Quinic acid ester | 0.02 | 0.013 |
| 1B | 3,5-Dicaffeoylquinic acid | Quinic acid ester | 0.04 | 0.07 |
| 2A | Pentagalloylglucose | Glucopyranoside | 0.04 | 0.046 |
| 2B | 3-O-(4-Hydroxyphenylpropanone)-1-glucopyranoside | Glucopyranoside | 1.1 | 0.66 |
| 3A | Rosmarinic acid | Phenolic | 0.05 | 0.12 |
| 4A | Miquelianin | Flavonoid | 0.18 | 0.18 |
| 4B | Myricetin | Flavonoid | 0.23 | 0.36 |
| 4C | Epicatechin | Flavonoid | 0.26 | 0.25 |
| 5 | 3-Hydroxy-1-(4-hydroxyphenyl)propan-1-one | Phenolic | 0.63 | 0.64 |