TABLE 1 .
Incidence of pathology in cynomolgus macaques infected with SHFV or with KRCV-1 followed by SHFV
| Type of observations, organ system | Finding(s) (no. of animals with finding/total no. in group) in: |
|
|---|---|---|
| KRCV-1-naive, SHFV-infected animals | KRCV-1-infected then SHFV-infected animals | |
| Macroscopic observations | ||
| Neurological | Meningeal congestion (2/4) | Meningeal edema (1/4) |
| Cardiopulmonary | Pericardial edema (1/4), pulmonary congestion (2/4) | Pericardial edema (1/4), pulmonary congestion (1/4) |
| Gastrointestinal | Duodenal congestion (2/4), jejunal congestion (2/4), ileal congestion (1/4) | Significant pathology not observed |
| Hepatic | Discoloration (1/4), congestion (2/4) | Significant pathology not observed |
| Hemolymphatic | Spleen congestion (2/4), peripheral lymphadenopathy (1/4), tracheobronchial lymphadenopathy (1/4) | Mesenteric lymphadenopathy (2/4), peripheral lymphadenopathy (2/4), tracheobronchial lymphadenopathy (1/4) |
| Integumentary | Dermal hemorrhage (1/4) | Dermal hemorrhage (2/4) |
| Adrenal | Hemorrhage (1/4) | Significant pathology not observed |
| Reproductive | Testicular congestion (1/4) | Testicular edema (2/4) |
| Histological observations | ||
| Pulmonary | Congestion (moderate in 3/4), edema (moderate in 1/4), lymphocytic/lymphohistiocytic inflammation (moderate in 1/4) | Congestion (mild in 1/4), edema (moderate in 1/4), lymphocytic/lymphohistiocytic inflammation (mild to moderate in 2/4) |
| Hepatic | Hepatocellular degeneration (mild to moderate in 4/4), hepatocellular necrosis (minimal in 1/4) | Hepatocellular degeneration (minimal to moderate in 4/4), hepatocellular necrosis (minimal in 1/4) |
| Hemolymphatic: | ||
| Spleen | Depletion (mild to moderate in 2/4), lymphoid degeneration and/or necrosis (minimal to moderate in 3/4) | Depletion (mild to moderate in 4/4), lymphoid necrosis (minimal to moderate in 3/4) |
| Lymph nodes: | ||
| Axillary | Depletion (minimal to mild in 2/4), necrosis (minimal to moderate in 3/4), histiocytosis (moderate in 1/4) | Depletion (mild in 4/4), necrosis (minimal to mild in 3/4), histiocytosis (mild in 4/4) |
| Inguinal | Depletion (moderate in 3/4), necrosis (minimal to mild in 2/4), histiocytosis (mild to moderate in 2/4) | Depletion (mild to moderate in 4/4), necrosis (mild 3/4), histiocytosis (mild to moderate in 3/4) |
| Mesenteric | Depletion (minimal to moderate in 3/4), necrosis (minimal to mild in 4/4), histiocytosis (mild to moderate in 2/4) | Depletion (minimal to mild in 4/4), necrosis (mild to moderate in 4/4), histiocytosis (mild to moderate in 4/4) |
| Tracheobronchial | Necrosis (moderate in 2/2) | Depletion (minimal to mild in 3/4), necrosis (minimal to mild in 3/4), histiocytosis (mild in 2/4) |
| Mandibular | Depletion (minimal to moderate in 3/3), necrosis (minimal to moderate in 2/3), histiocytosis (mild in 2/3) | Depletion (minimal to moderate in 4/4), necrosis (mild to moderate in 4/4), histiocytosis (minimal to moderate in 4/4) |
| Renal (kidney) | Lymphocytic/lymphohistiocytic inflammation (mild in 1/4) | Lymphocytic/lymphohistiocytic inflammation (mild in 2/4) |