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. 2016 Mar 14;17:124. doi: 10.1186/s12891-016-0979-x

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© van den Akker et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — EGR1 controls inflammatory responses in IVD cell clones. Induction of COX2 (a) TNFα (b) MMP3 (c) and ADAMTS4 (d) expression measured by qPCR. Sixteen hours after siRNA transfection cells were harvested (time point t = 0) and stimulated with IL-1β for 2 and 48 h. Induced mRNA levels are expressed relative (FC) to siCTRL, t = 0, for each cell type. Double asterisks (**) indicate significantly different expression levels between siCTRL and siEGR1 measurements at the indicated time points (p < 0.05); single asterisks (*) indicate significance (p < 0.05) compared to time point t = 0 of that series (siCTRL or siEGR1)