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. 2016 Mar 15;4:13. doi: 10.1186/s40425-016-0117-1

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© Koelzer et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Morphological progression from initial diagnosis. a Melanoma ex naevo (08/2012) b local recurrence (08/2013) with deep in transit metastasis and c sentinel node metastasis d skin metastasis (10/2014) e dedifferentiated melanoma at autopsy f intratumoral CD8-positive T-cell infiltrates at autopsy as detected by immunohistochemistry; scale bars as indicated