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. 2016 Mar 15;4:13. doi: 10.1186/s40425-016-0117-1

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© Koelzer et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Lung damage patterns. a CT Thorax: Pulmonary metastasis before therapy with Ipilimumab (02/2015) b CT Thorax: pulmonary metastasis regression, ground glass opacities after Ipilimumab (04/2015) c sarcoid-like reaction d elastica stain showing epithelioid granulomas surrounded by fibrotic rings e CD8-positive T-cell infiltrates surrounding giant cell granulomas as detected by immunohistochemistry f diffuse alveolar damage; scale bars as indicated