Table 1.

Systemic manifestations oh HFMD [14, 15]

Systemic features of HFMD	Systemic features in severe occurrences of HFMD
Anorexia, fever, low pollution, sore throat, runny nose, abdominal pain, and sometimes myalgia, lymphadenopathy, diarrhea, nausea and vomiting	Skin rashes, fever ≥38 °C, neurological symptoms, respiratory symptoms such as tachypnea or bradypnea, pulmonary edema, cardiovascular symptoms such as tachycardia and hypertension, bleeding, pulmonary consolidation, hyperglycemia, elevated leukocyte and high levels of lactic acid