. 2016 Mar 15;16:35. doi: 10.1186/s12876-016-0455-y

Table 2.

Comparison between children in group A (age at diagnosis of Inflammatory Bowel Disease between 5 and 10 years) and those in group B (age at diagnosis of Inflammatory Bowel Disease between 11 and 16 years): disease activity and location at presentation (A), biochemical parameters at disease presentation (B), disease course and outcomes (C)

Variables	All Group A vs Group B	Brit^a Group A vs Group B	Ita^b Group A vs Group B
A. Disease activity and location at presentation
Disease activity
CD^c (PCDAI^d)
Group A: mean ± SD^e	38.75 ± 2.7	45 ± 3.3	31.3 ± 3.44
Group B:mean ± SD	30.76 ± 2.02	32.2 ± 2.26	29.6 ± 3.5
P	*0.05*	*0.003*	0.7
UC^f (PUCAI^g)
Group A: mean ± SD	47.2 ± 2.5	55.2 ± 2.2	41.2 ± 2.7
Group B: mean ± SD	41.4 ± 1.8	41.6 ± 2.5	39.8 ± 3.65
P	*0.03*	*0.03*	0.8
OR^h	1.09	1.11	1.03
95 % CIⁱ	1.02–1.1	1.03–1.2	1.01–1.08
Disease location
CD
P	0.3 for L1	0.6 for L1	0.3 for L1
	*0.05* for L2	*0.04* for L2	0.7 for L2
	0.4 for L3	0.5 for L3	0.7 for L3
UC
P	0.7 for E1–E2	0.8 for E1–E2	0.6 for E1–E2
P	0.8 for E3–E4	0.9 for E3–E4	0.9 for E3–E4
B. Biochemical parameters at disease presentation
WBC^j (x10^3/mm3)
Group A: mean ± SD	10.1 ± 0.45	10.9 ± 0.7	9.4 ± 0.6
Group B: mean ± SD	8.81 ± 0.35	9.09 ± 0.5	8.5 ± 0.47
P	*0.03*	*0.04*	0.3
HCT^k (%)
Group A: mean ± SD	33.7 ± 0.57	32.6 ± 0.6	34.8 ± 0.9
Group B: mean ± SD	35.8 ± 0.5	34.9 ± 0.7	36.7 ± 0.6
P	*0.005*	*0.02*	0.09
Platelet count (x10^3/mm3)
Group A: mean ± SD	487 ± 18.9	476 ± 21.3	497.5 ± 31.2
Group B: mean ± SD	393 ± 13.4	404 ± 18.6	382 ± 19.3
P	*0.002*	*0.01*	*0.003*
C. Disease course and outcomes
Early treatment with thiopurines (within 3 months of diagnosis)
Group A	58	20	38
Group B	46	17	29
P	*0.05*	0.7	*0.006*
OR	1.86	1.04	7.19
95 % CI	1.02–4.33	0.8–2.63	0.9–77.4
Relapses (per patient/per year of follow-up)
Group A: mean ± SD	1.4 ± 0.2	1.53 ± 1.24	1.03 ± 0.3
Group B: mean ± SD	0.85 ± 0.1	0.9 ± 0.7	0.7 ± 0.13
P	*0.05*	*0.005*	0.3
OR	1.2	1.5	1.2
95 % CI	1.01–1.65	0.8–4.45	0.74–2.64
Number of endoscopies (per patient/per year of follow-up)
Group A: mean ± SD	0.9 ± 0.05	0.9 ± 0.06	0.9 ± 0.09
Group B: mean ± SD	0.75 ± 0.05	0.8 ± 0.07	0.7 ± 0.08
P	*0.04*	0.2	*0.05*
OR	1.67	1.2	7.07
95 % CI	1.01–4.19	0.98–1.58	1.09–45.9

^a Brit British

^b Ita Italian

^c CD Crohn’s disease

^d PCDAI paediatric Crohn’s disease activity index

^e SD standard deviation

^f UC ulcerative colitis

^g PUCAI paediatric ulcerative colitis activity index

^h OR odds ratio

ⁱ CI confidence interval

^j WBC white blood cells

^k HCT haematocrit