Amino acid neurotransmitters levels in the PL cortex do not differ between strains. Basal levels of serine, glycine, glutamate, and GABA were assessed in naïve Sprague Dawley (SD, n=6) and Wistar Kyoto (WKY, n=8) rats by microdialysis and high-performance liquid chromatography with electrochemical detection (HPLC-EC). All values are based on a standard and have been corrected for differences probe efficiency. No significant differences were observed in neurotransmitter levels between strains; however, glutamate did trend lower in WKY rats. P-values were generated by independent samples t-test.