Abstract
The genus Himatanthus Wild. ex Schult. (Apocynaceae) includes about 13 species and five subspecies widely distributed in South America, especially Brazil. The phytochemical reports on this genus have revealed mainly triterpenes and iridoids. The plants are traditionally used as anthelmintic, antitumor, and antiinflammatory agents. The most used parts of the plant are its bark, leaves, and latex. This review emphasizes the phytochemical constituents and medicinal properties, which may help in future research. The research was conducted with data obtained from books about medicinal plants, theses, dissertations, and articles in refereed journals.
Keywords: Biological effects, botanical, ethnopharmacology, folk medicine, Himatanthus, phytochemistry
INTRODUCTION
The Apocynaceae family includes approximately 550 genuses and 3700–5100 species distributed in all continents except Antarctica. It is a rich source of secondary metabolites, because of which many of the genuses belonging to it, such as Rauwolfia, Catharanthus, Allamanda, Strophantus, and Himatanthus, are used on a large scale for medicinal use by small communities and/or pharmaceutical industry.[1]
In this review, we will be focused on the folk medicine uses, biological effects, and phytochemistry of the genus Himatanthus Willd. Ex Schult., in order to provide a basis for several different research areas, such as the botanic, pharmaceutical, medical, and chemical fields.
MATERIALS AND METHODS
The method used for this study was based on bibliographical research into books about medicinal plants, theses, dissertations, and articles in refereed journals. Presentations at conferences and symposia were not considered.
We performed extensive research in the Periodicals Portal of Capes (Coordination for the Improvement of Higher Education Personnel), which has several databases such as Chemical Abstracts, PubMed, Web of Science and Science Direct (consultation period: February to May 2014). The key word used in the research was Himatanthus; information on the plant parts used, the uses in folk medicine, the biological activities, and the chemical constituents was collected.
Data were compiled and organized into a table [Table 1], and the Himatanthus species have been arranged in alphabetical order.
Table 1.
List of Himatanthus species and plant parts used, folk medicine uses, biological properties, and chemical constituents
RESULTS AND DISCUSSIONS
The genus Himatanthus Willd. Ex Schult., initially included in the genus Plumeria, has large bracts involving the floral buttons, determinants for the separation of genus. The presence of these bracts has inspired the naming of this genus, which means “flower robe.”[59]
It encompasses 13 species: H. articulatus (Vahl) Woodson, H. attenuatus (Benth.) Woodson, H. bracteatus (A.DC.) Woodson, H. drasticus (Mart.) Plumel, H. fallax (Muell. Arg.) Plumel, H. lancifolius (Muell. Arg.) Woodson, H. obovatus (Muell. Arg.) Woodson, H. phagedaenicus (Mart.) Woodson, H. semilunatus Markgraf, H. speciosus (Muell. Arg.) Plumel, H. stenophyllus Plumel, H. sucuuba (Spruce) Woodson, and H. tarapotensis (Schumann ex Markgraf) Plumel.[22,60] There are also five varieties of these species: H. bracteatus var. bracteatus, H. bracteatus var. revolutus, H. obovatus var. obovatus, H. obovatus var. puberulus, and H. obovatus var. velutinus.[60] They all occur in Brazil and some other countries in South and Central America.[22,60]
From among the 13 species of Himatanthus, four did not have any research records concerning their chemical composition and medicinal properties: H. attenuatus, H. semilunatus, H. speciosus, and H. tarapotensis. The research results with the other species are summarized in Table 1.
The H. bracteatus, H. fallax, and H. stenophyllis species have only reports of chemical composition studies, and the presence of the iridoid plumieride in the bark of these species is common.[10,21] This substance and the isoplumieride, generally, are present in the bark, latex, leaves, and/or roots of the species of Himatanthus.[2,10,21,23,36,38,41] This kind of spirolactone iridoid is not commonly found in nature. Some studies revealed that plumieride exhibits antimicrobial[61] and antioxidant effects,[62] arrests spermatogenesis in male rats without noticeable side effects, and presents cytotoxicity.[3]
The H. articulatus, H. drasticus, H. lancifolius, H. obovatus, H. phagedaenicus, and H. sucuuba species presented chemical and biological studies, and in general the barks are the most studied, followed by the leaves.
Although the presence of alkaloids in the barks of H. articulates is reported,[2] only from the barks of H. lancifolius were they isolated and identified,[24,25] and these are indole and have antimicrobial, gastroprotective, antiinflammatory, and antioxidant properties and showing cytotoxic activity against tumor cells.[26,27,28,29,30] However, there are no data on the ethnopharmacological use of the plant as an antitumor agent.[23,30,31]
H. articulatus latex is popular as an antifungal and antitumor agent, these effects evidenced by biological studies.[4] Their barks showed cytotoxic and trypanocidal and leishmanicidal effects, also reported in folk medicine.[2,3,5,6] Leishmaniasis is a parasitic disease responsible for considerable mortality and morbidity, affecting many people every year.[4] Leishmania donovani is the causative agent of visceral leishmaniasis, which is fatal in the absence of treatment.[63] Its various side effects and resistance to available drugs, in addition to the increase in new cases, have led to an urgent need for new therapeutic agents. This activity was also determined in H. articulatus leaves, H. obovatus roots, and H. sucuuba latex,[4,36,42] which are certainly promising sources of treatment.
There are studies of H. drasticus latex evaluating its antiulcerogenic, antitumor, analgesic, and antiinflammatory activities, which somehow justify their popular uses in the treatment of cancer, gastric disorders, rheumatism, and bruises.[1,11,12,13,14,15,16,17,18]
H. sucuuba is the most studied species, with a record of chemical composition of the latex, bark, leaves, roots and leaves, and the presence of triterpene amyrin cinnamate.[41,43,44,45,46] Latex, bark, and leaves have antitumor action, justifying the popular use for the same purpose.[41,46,47,48,49,50] The latex and bark showed antiinflammatory and analgesic effects, which are reasons for some popular uses of the plant: In treatment of arthritis, boils, and edema.[41,44,46,48,49,50]
Biological studies on H. obovatus roots have no relation with the ethnopharmacological information about the plant.[36] However, the popular use of the leaves as antitumor agent[36] can be justified by the presence of iridoids and triterpene esters.
The triterpenoids are considered promising anticancer drugs due to their diverse pharmacological activities, including antiangiogenic, antiinflammatory, and antioxidant effects and the ability to increase cell differentiation.[64] These compounds, along with iridoids, are certainly responsible for most of the plant's medicinal properties reported in both folk medicine and biological studies.
CONCLUSION
Among the nine species studied, six species were evaluated chemically and biologically. The most studied species was H. sucuuba.
In general, the species are traditionally used as an anthelmintic, antitumor, and antiinflammatory agent. There were no evaluation studies of anthelmintic activity for any species of the genus; however, there are several studies evaluating antitumor and antiinflammatory activities.
Regarding the chemical composition, the genus is distinguished by the presence of triterpene esters and iridoids, predominantly in the bark and leaves. These compounds exhibit valuable pharmacological properties such as antimicrobial, antioxidant, antiinflammatory, and antitumor properties, which warrant further exploration.
The chemical and pharmacological data presented in this study should inspire further study of the species of Himatanthus for future use in therapies, including treatment of leishmaniasis.
Financial support and sponsorship
Nil.
Conflicts of interest
There is no conflicts of interest with this article.
ABOUT AUTHORS
Fabiana P. Soares
Fabiana P. Soares, Professor of Pharmacognosy at the University of Fortaleza (UNIFOR), pharmaceutical and PhD in Development and Technological Innovation in Medicines (PPGDITM), Federal University of Ceara (UFC), Brazil.
Larissa F. Cavalcante
Larissa F. Cavalcante, Degree in Pharmacy, University of Fortaleza (UNIFOR), Brazil.
Nirla Rodrigues Romero
Nirla Rodrigues Romero, Professor of Pharmaceutical Chemistry at the Federal University of Ceara (UFC), pharmaceutical, PhD in Chemistry and coordinator of Pharmacy course at the UFC, Brazil.
Mary A. M. Bandeira
Mary A. M. Bandeira, Professor of Pharmacognosy at the Federal University of Ceara (UFC), pharmaceutical, PhD in Chemistry; director of “Francisco José de Abreu Matos” Medicinal Plants Horto of the UFC, Brazil.
Acknowledgment
We have not received substantial contributions from noncontributors, and no contributor has been omitted.
REFERENCES
- 1.Moragas CJ. Brasil: Universidade Federal do Rio de Janeiro; 2006. Study of the Genre Himatanthus: Plant Anatomy, Phytochemical, Pharmacological and Biotransformation. PhD Thesis; p. 287. [Google Scholar]
- 2.Barreto AS, Carvalho MG, Nery IA, Gonzaga L, Kaplan MA. Chemical constituents from Himatanthus articulata. J Braz Chem Soc. 1998;9:430–4. [Google Scholar]
- 3.Rebouças Sde O, Grivicich I, Dos Santos MS, Rodriguez P, Gomes MD, de Oliveira SQ, et al. Antiproliferative effect of a traditional remedy, Himatanthus articulatus bark, on human cancer cell lines. J Ethnopharmacol. 2011;137:926–9. doi: 10.1016/j.jep.2011.06.006. [DOI] [PubMed] [Google Scholar]
- 4.Sequeira BJ, Vital MJ, Pohlit AM, Pararols IC, Caúper GS. Antibacterial and antifungal activity of extracts and exudates of the Amazonian medicinal tree Himatanthus articulatus (Vahl) Woodson (common name: sucuba) Mem Inst Oswaldo Cruz. 2009;104:659–61. doi: 10.1590/s0074-02762009000400022. [DOI] [PubMed] [Google Scholar]
- 5.Mesquita ML, Desrivot J, Bories C, Fournet A, Paula JE, Grellier P, et al. Antileishmanial and trypanocidal activity of Brazilian Cerrado plants. Mem Inst Oswaldo Cruz. 2005;100:783–7. doi: 10.1590/s0074-02762005000700019. [DOI] [PubMed] [Google Scholar]
- 6.Rebouças SO, Silva J, Groff AA, Nunes EA, Ianistcki M, Ferraz AB. The antigenotoxic activity of latex from Himatanthus articulatus. Braz J Pharmacog. 2012;22:389–96. [Google Scholar]
- 7.Elizabetsky E, Castilhos C. Plants used as analgesics by Amazonian caboclos as a basis for selecting plants for investigation. Int J Crude Drug Res. 1990;28:309–20. [Google Scholar]
- 8.Van Den Berg ME. Belém: Adolpho Ducke Collection; 1993. Medicinal plants of the Amazon: Contribution to its systematic knowledge; p. 135. [Google Scholar]
- 9.Milliken W. Kew: Royal Botanic Garden; 1995. Plants used in the treatment of malaria in Roraima state – Preliminary report; p. 67. [Google Scholar]
- 10.Ferreira JL, Amaral AC, Araujo RB, Carvalho JR, Proença CE, Fraga SA, et al. Pharmacognostical comparison of three species of Himatanthus. Int J Bot. 2009;5:171–5. [Google Scholar]
- 11.Colares AV, Cordeiro LN, Costa JG, Silveira ER, Campos AR, Cardoso AH. Phytochemical and biological preliminary study of Himatanthus drasticus (Mart.) Plumel (janaguba) Pharmacogn Mag. 2008;4:73–7. [Google Scholar]
- 12.Leite GO, Penha AR, Silva GQ, Colares AV, Rodrigues FF, Costa JG, et al. Gastroprotective effect of medicinal plants from Chapada do Araripe, Brazil. J Young Pharm. 2009;1:54–6. [Google Scholar]
- 13.Sousa EL. Brazil: Federal University of Pernambuco, Recife, Pernambuco; 2009. Atividade Anti-tumoral de Himatanthus drasticus (Mart.) Plumel-Apocynaceae (Janaguba).) Dissertation; p. 93. [Google Scholar]
- 14.Lucetti DL, Lucetti EC, Bandeira MA, Veras HN, Silva AH, Leal LK, et al. Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel. J Inflamm (Lond) 2010;7:60. doi: 10.1186/1476-9255-7-60. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Sousa EL, Grangeiro AR, Bastos IV, Rodrigues GC, Silva MJ, Anjos FB, et al. Antitumor activity of leaves of Himatanthus drasticus (Mart.) Plumel – Apocynaceae (Janaguba) in the treatment of sarcoma 180 tumor. Braz J Pharm Sci. 2010;46:199–203. [Google Scholar]
- 16.França WC, Souza AC, Cordeiro JA, Cury PM. Analysis of the action of Himatanthus drasticus in progression of urethane-induced lung cancer in mice. Einstein. 2011;9:350–3. doi: 10.1590/S1679-45082011AO2013. [DOI] [PubMed] [Google Scholar]
- 17.Mousinho KC, Oliveira Cde C, Ferreira JR, Carvalho AA, Magalhães HI, Bezerra DP, et al. Antitumor effect of laticifer proteins of Himatanthus drasticus (Mart.) Plumel – Apocynaceae. J Ethnopharmacol. 2011;137:421–6. doi: 10.1016/j.jep.2011.04.073. [DOI] [PubMed] [Google Scholar]
- 18.Matos FJ. Fortaleza, CE: UFC Editions; 1999. Plants of the Northeast Popular Medicine: assigned and confirmed properties; p. 78. [Google Scholar]
- 19.Lorenzi H, Matos FJ. Nova Odessa: Plantarun Institute; 2008. Medicinal plants in Brazil: native and exotic; pp. 68–9. [Google Scholar]
- 20.Colares AV, Cordeiro LN, Costa JG, Campos AR, Cardoso AH. Gastroprotective effect of Himatanthus drasticus (Mart.) Plumel (janaguba) latex. Infarma Pharm Sci. 2008;20:34–6. [Google Scholar]
- 21.Abdel-Kader MS, Wisse J, Evans R, van der Werff H, Kingston DG. Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest. J Nat Prod. 1997;60:1294–7. doi: 10.1021/np970253e. [DOI] [PubMed] [Google Scholar]
- 22.Plumel MM. Geographical distribution of Himatanthus em like Tropical America. CR Soc Biogeogr. 1990;66:103–27. [Google Scholar]
- 23.Baratto LC. Brazil: Federal University of Paraná; 2010. Chemical-analytical and morpho-anatomical study of Brazilian medicinal species of Apocynaceae family: Himatanthus lancifolius and Ralvolfia sellowii. Dissertation; p. 152. [Google Scholar]
- 24.Lopes JF. Brazil: Federal University of Paraná; 2008. Yohimbine and uleine isolated of Himatanthus lancifolius (Muell.-Arg.) Woodson, Apocynaceae. Dissertation; p. 79. [Google Scholar]
- 25.França OO, Brown RT, Santos CA. Uleine and demethoxyaspidospermine from the bark of Plumeria lancifolia. Fitoterapia. 2000;71:208–10. doi: 10.1016/s0367-326x(99)00141-0. [DOI] [PubMed] [Google Scholar]
- 26.Souza WM, Stinghen AE, Santos CA. Antimicrobial activity of alkaloidal fraction from barks of Himatanthus lancifolius. Fitoterapia. 2004;75:750–3. doi: 10.1016/j.fitote.2004.09.012. [DOI] [PubMed] [Google Scholar]
- 27.Baggio CH, De Martini Otofuji G, de Souza WM, de Moraes Santos CA, Torres LM, Rieck L, et al. Gastroprotective mechanisms of indole alkaloids from Himatanthus lancifolius. Planta Med. 2005;71:733–8. doi: 10.1055/s-2005-871286. [DOI] [PubMed] [Google Scholar]
- 28.Rattmann YD, Terluk MR, Souza WM, Santos CA, Biavatti MW, Torres LB, et al. Effects of alkaloids of Himatanthus lancifolius (Muell. Arg.) Woodson, Apocynaceae, on smooth muscle responsiveness. J Ethnopharmacol. 2005;100:268–75. doi: 10.1016/j.jep.2005.02.041. [DOI] [PubMed] [Google Scholar]
- 29.Souza WM, Brehmer F, Nakao LS, Stinghen AE, Santos CA. Uleine effect on the production of nitric oxide in RAEC and B16F10 cells. Braz J Pharmacog. 2007;17:191–6. [Google Scholar]
- 30.Souza WM. Brazil: Federal University of Paraná, Curitiba; 2007. Chemical and biological activities of indole alkaloids of Himatanthus lancifolius (Muell. Arg.) Woodson, Apocynaceae – (agoniada). Phd Thesis; p. 152. [Google Scholar]
- 31.Corrêa MP. Vol. 1. Rio de Janeiro: National Press; 1984. Dictionary of useful plants in Brazil and cultivated exotic; p. 747. [Google Scholar]
- 32.Baratto LC, Hohlemwerger SV, Guedes ML, Duarte MR, Santos CA. Himatanthus lancifolius (Müll. Arg.) Woodson, Apocynaceae: Morpho-anatomical study of a medicinal plant described in the Brazilian Pharmacopoeia 1st edition. Braz J Pharmacog. 2010;20:651–8. [Google Scholar]
- 33.Nardin JM, de Souza WM, Lopes JF, Florão A, de Moraes Santos CA, Weffort-Santos AM. Effects of Himatanthus lancifolius on human leukocyte chemotaxis and their adhesion to integrins. Planta Med. 2008;74:1253–8. doi: 10.1055/s-2008-1074582. [DOI] [PubMed] [Google Scholar]
- 34.Nardin JM, Lima MP, Machado JC, Jr, Hilst LF, Santos CA, Weffort-Santos AM. The uleine-rich fraction of Himatanthus lancifolius blocks proliferative responses of human lymphoid cells. Planta Med. 2010;76:697–700. doi: 10.1055/s-0029-1240648. [DOI] [PubMed] [Google Scholar]
- 35.Lima MP, Hilst LF, Mattana FV, Santos CA, Weffort-Santos AM. Alkaloid-rich fraction of Himatanthus lancifolius contains anti-tumor agents against leukemic cells. Braz J Pharm Sci. 2010;46:273–80. [Google Scholar]
- 36.Lima VB. Brazil: Institute of Chemistry, State University of Campinas; 2005. [Last accessed on 2014 May 11]. Phytochemical study of Himatanthus obovatus (Muell Arg.) Woodson (Apocynaceae): isolation, structure elucidation and biological activity. Phd Thesis. Available from: http://biq.iqm.unicamp.br/arquivos/teses/vtls000365948.pdf . [Google Scholar]
- 37.Souza-Fagundes EM, Queiroz AB, Martins Filho OA, Gazzinelli G, Corrêa-Oliveira R, Alves TM, et al. Screening and fractionation of plant extracts with antiproliferative activity on human peripheral blood mononuclear cells. Mem Inst Oswaldo Cruz. 2002;97:1207–12. doi: 10.1590/s0074-02762002000800024. [DOI] [PubMed] [Google Scholar]
- 38.Vanderlei MF, Silva MS, Gottlieb HE, Braz-Filho R. Iridoids and triterpenes from Himatanthus phagedaenicus: The complete assignement of the 1H and 13C NMR spectra of two iridoid glycosides. J Braz Chem Soc. 1991;2:51–8. [Google Scholar]
- 39.Vanderlei MF, Brito AR. Espasmogenic actions of the ethanol extract of Himatanthus phagedaenicus (Mart.) Woodson in isolated Guinea pig ileum. Cad Farm. 1989;5:49–71. [Google Scholar]
- 40.Veloso MP, Nagem TJ, de Oliveira TT. Dihidroplumericinic acid from Himatanthus phagedaenicus. Biochem Syst Ecol. 1999;27:669–71. [Google Scholar]
- 41.Amaral AC, Silva JR, Ferreira JL, Pinheiro ML. Monograph of Himatanthus sucuuba, a plant of Amazonian folk medicine. Pharmacogn Rev. 2007;1:305–13. [Google Scholar]
- 42.Castillo D, Arevalo J, Herrera F, Ruiz C, Rojas R, Rengifo E, et al. Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae) J Ethnopharmacol. 2007;112:410–4. doi: 10.1016/j.jep.2007.03.025. [DOI] [PubMed] [Google Scholar]
- 43.Silva JR, Rezende CM, Pinto AC, Pinheiro ML, Cordeiro MC, Tamborini E, et al. Triterpenic esters from Himatanthus sucuuba (Spruce) Woodson. Quim Nova. 1998;21:702–4. [Google Scholar]
- 44.de Miranda AL, Silva JR, Rezende CM, Neves JS, Parrini SC, Pinheiro ML, et al. Anti-inflammatory and analgesic activities of the latex containing triterpenes from Himatanthus sucuuba. Planta Med. 2000;66:284–6. doi: 10.1055/s-2000-8572. [DOI] [PubMed] [Google Scholar]
- 45.Wood CA, Lee K, Vaisberg AJ, Kingston DG, Neto CC, Hammond GB. A bioactive spirolactone iridoid and triterpenoids from Himatanthus sucuuba. Chem Pharm Bull (Tokyo) 2001;49:1477–8. doi: 10.1248/cpb.49.1477. [DOI] [PubMed] [Google Scholar]
- 46.Graebner IB. Brazil: Federal University of Santa Maria; 2003. Study of chemical constituents isolated from medicinal plants of the Vale do Purus in Acre (Amazon). Phd Thesis; p. 116. [Google Scholar]
- 47.Silva JR, Rezende CM, Pinto AC, Amaral AC. Cytotoxicity and antibacterial studies of iridoids and phenolic compounds isolated from the latex of Himatanthus sucuuba. Afr J Biotechnol. 2010;9:7357–60. [Google Scholar]
- 48.Larrosa CR, Duarte MR. Contribution to the anatomical study of the stem of Himatanthus sucuuba (Spruce ex Müll. Arg.) Woodson, Apocynaceae. Braz J Pharmacog. 2005;15:110–4. [Google Scholar]
- 49.Villegas LF, Fernández ID, Maldonado H, Torres R, Zavaleta A, Vaisberg AJ, et al. Evaluation of the wound-healing activity of selected traditional medicinal plants from Perú. J Ethnopharmacol. 1997;55:193–200. doi: 10.1016/s0378-8741(96)01500-0. [DOI] [PubMed] [Google Scholar]
- 50.Di Stasi LC, Hiruma-Lima CA. São Paulo: Unesp Publisher; 2002. Medicinal plants in the Amazon and Atlantic Forest; p. 604. [Google Scholar]
- 51.Perdue GP, Blomster RN. South American plants III: Isolation of fulvoplumierin from Himatanthus sucuuba (M. Arg.) Woodson (Apocynaceae) J Pharm Sci. 1978;67:1322–3. doi: 10.1002/jps.2600670936. [DOI] [PubMed] [Google Scholar]
- 52.Endo Y, Hayashi H, Sato T, Maruno M, Ohta T, Nozoe S. Confluentic acid and 2’-O-methylperlatolic acid, monoamine oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba. Chem Pharm Bull (Tokyo) 1994;42:1198–201. doi: 10.1248/cpb.42.1198. [DOI] [PubMed] [Google Scholar]
- 53.Fernandes MZ, Fernandes RM, Sousa MC, Lopes JB. Determination of acute toxicity of Himatanthus sucuuba (Spruce) Woodson (Apocynaceae) in mice. Rev Bras Farm. 2000;81:98–100. [Google Scholar]
- 54.Silva JR, Amaral AC, Siani AC, Rezende CM, Felcman J, Pinto AC. Contribution to the study of Himatanthus sucuuba: Látex macromolecule, microfilaments and carbohydrates. Acta Amazon. 2003;33:105–10. [Google Scholar]
- 55.Morel AF, Graebner IB, Porto C, Dalcol II. Study on the antimicrobial activity of Hymatanthus sucuba. Fitoterapia. 2006;77:50–3. doi: 10.1016/j.fitote.2005.08.012. [DOI] [PubMed] [Google Scholar]
- 56.Barreto AS, Amaral AC, Silva JR, Schripsema J, Rezende CM, Pinto AC. 15-demethylisoplumieride acid, a new iridoid isolated from the bark of Plumeria rubra and latex of Himatanthus sucuuba. Quim Nova. 2007;30:1133–5. [Google Scholar]
- 57.Soares DC, Andrade AL, Delorenzi JC, Silva JR, Freire-de-Lima L, Falcão CA, et al. Leishmanicidal activity of Himatanthus sucuuba latex against Leishmania amazonensis. Parasitol Int. 2010;59:173–7. doi: 10.1016/j.parint.2010.01.002. [DOI] [PubMed] [Google Scholar]
- 58.Waltenberger B, Rollinger JM, Griesser UJ, Stuppner H, Gelbrich T. Plumeridoid C from the Amazonian traditional medicinal plant Himatanthus sucuuba. Acta Crystallogr C. 2011;67(Pt 10):o409–12. doi: 10.1107/S0108270111035761. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 59.Plumel MM. The genre Himatanthus (Apocynaceae). Taxonomic revision: Brandea. Bol Herb Bradeanu. 1991;5:1–20. [Google Scholar]
- 60.Forzza RC. Vol. 1. Rio de Janeiro: Andrea Jakobsson Studio/Institute of Research Botanical Garden of Rio de Janeiro; 2010. Catalog of plants and fungi of Brazil; p. 626. [Google Scholar]
- 61.Tiwari TN, Pandey VB, Dubey NK. Plumieride from Allamanda cathartica as an antidermatophytic agent. Phytother Res. 2002;16:393–4. doi: 10.1002/ptr.967. [DOI] [PubMed] [Google Scholar]
- 62.Singh D, Arya PV, Sharma A, Aggarwal VP, Dobhal MP, Gupta RS. Antioxidant potential of plumieride against CCL4-induced peroxidative damage in rats. Antioxidants. 2014;3:798–813. doi: 10.3390/antiox3040798. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 63.Paris C, Loiseau PM, Bories C, Breard J. Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes. Agents Chemother. 2004;48:852–9. doi: 10.1128/AAC.48.3.852-859.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 64.Laszczyk MN. Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy. Planta Med. 2009;75:1549–60. doi: 10.1055/s-0029-1186102. [DOI] [PubMed] [Google Scholar]