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. 2016 Mar 14;212(6):707–719. doi: 10.1083/jcb.201507054

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© 2016 Le et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — Cartoon model of SLIT2/ROBO1 signaling circuit. (1) Increased ECM stiffness down-regulates miR-203 derepressing Robo1. (2) ROBO1 expression is increased. (3) SLIT2/ROBO1 signals through Sos1/Rac to activate FAK; Rac also contributes to NMII activation. (4) This results in FA maturation and (5) enhanced cell contractility.