Table 1.
Patients characteristics and potential prognostic factors
| ITT population | N = 134 |
|---|---|
| Gender (%) F/ M | 15 (11.2)/119 (88.8) |
| Median Age (years, min/max) | 65.3 [42.1–88.2] |
| [35–50 [N (%) | 7 (5.2) |
| [50–65 [N (%) | 57 (42.5) |
| [65–75 [N (%) | 42 (31.3) |
| ≥75 N (%) | 28 (20.8) |
| Performance Status N (%) | |
| 0/1/ ≥ 2/Na | 34 (25.4)/62 (46.3)/31 (23.1)/7 (5.2) |
| Metastases N (%) | |
| Lung/Liver/Bone/Lung + Liver/Other | 52 (38.8)/38 (28.4)/32 (23.9)/76 (56.7)/20 (14.9) |
| Creatinine Clearance N (%) | |
| >60 ml/mn/[40–60] ml/mn/ < 40 ml/mn/Na | 67 (50.0)/51 (38.1)/13 (9.7)/3 (2.2) |
| Haemoglobin N (%) | |
| <= 10 (g/dl)/ > 10 (g/dl)/Na | 32 (23.9)/100 (74.6)/2 (1.5) |
| Liver Function N (%) | |
| Normal/Abnormal/Na | 114 (85.1)/13 (9.7)/2 (1.5) |
| Chronic Constipation N (%) | |
| No/Yes/Na | 127 (94.8)/6 (4.5)/1 (0.7) |
| Prior Radiotherapy N (%) | 28 (20.9) |
| Progression within 6 months after prior CT N (%) | 112 (83.6) |
| Number of Advanced or Metastatic CT at Baseline [N, (%)] Total pts | 128 (95.5) |
| 1 CT lines | 93 (69.4) |
| 2 CT lines | 31 (23.1) |
| 3 CT lines | 4 (3) |
| Patients with perioperative CT alone at Baseline [N, (%)] | 5 (3.7 %) |