Table 2.

Heart Failure with Preserved Ejection Fraction definition and exclusion criteria use in the studies included in the meta-analysis

Trial	Criteria used for Defining HFPEF	Exclusion Criteria
Gary et al 200416	NYHA Class II or III Diastolic Heart Failure on chart review. Ejection Fraction > 50% Stabilized on cardiac medications for at least 3 months	Significant coronary artery disease Renal insufficiency, uncontrolled hypertension
Kitzman et al 201017 & Kitzman et al 201321	Symptoms and signs defined by NHANES HF score >3 History of acute pulmonary edema OR At least 2 of the following symptoms: dyspnea on exertion, paroxysmal nocturnal dyspnea, orthopnea, lower-extremity edema, or exertional fatigue. Well compensated, stabilized on cardiac medications for at-least 6 weeks	Significant coronary artery disease, valvular heart disease or pulmonary disease, anemia
Edelmann et al 201118	Symptomatic (NYHA II/III) with ejection fraction > 50% Echo determined diastolic dysfunction in sinus rhythm, At least 1 cardiovascular risk factor Stabilized on cardiac medications for at least 4 weeks	Significant coronary artery disease, valvular heart disease or pulmonary disease, anemia, uncontrolled Hypertension, arrhythmia
Smart et al 201220	Significant Dyspnea on exertion with Delayed relaxation or Pseudonormal filling on echo.	Hx of coronary artery disease COPD, Valvular disease
Alves et al 201219	Signs and symptoms of heart failure with ejection fraction > 55%	Uncontrolled Hypertension, unstable angina, abnormal hemodynamic response, arrhythmias, ischemic EKG changes during treadmill test