Table 1. . miRNAs associated with doxorubicin resistance.

miRNA	Change in resistant tumor	Cell type	Target gene(s)	Ref.
miR-215	↑	Hepatocyte	DHFR, TS	[111]
miR-26b	↓	Hepatocyte	TAK1, TAB3	[58]
miR-122	↑	Hepatocyte	Cyclin G1	[106]
miR-199a–3p	↓	Hepatocyte	mTOR, c-Met	[110]
miR-519d	↑	Hepatocyte	P21, PTEN, AKT3, TIMP2	[112]
miR-101	↓	Hepatocyte	EZH2	[109]
miR-223	↓	Hepatocyte	ABCB1	[108]
Let–7a	↑	Hepatocyte, SCC	Caspase–3	[125]
miR-138	↓	HNSCC	MDR1	[126]
miR-21	↑	Breast	PTEN	[127]
miR-760	↓	Breast	RHOB, ANGPTL4, ABCA1	[128]
miR-218	↓	Breast	Survivin	[129]
miR-298	↓	Breast	MDR1	[130]
miR-450b–3p	↓	Breast	HER3	[131]
miR-451	↓	Breast	MDR1	[132]
miR-452	↓	Breast	IGF–1R	[133]
miR-200c	↓	Breast	ZEB1	[134]
miR-34a	↓	Breast	NOTCH1	[135]
miR-34c	↓	Osteosarcoma	NOTCH1, LEF1	[136]
miR-382	↓	Osteosarcoma	HIPK3	[137]
miR-301a	↑	Osteosarcoma	AMPKα1	[138]
miR-708	↓	Ewing sarcoma	EYA3	[139]
miR-125b	↑	Ewing sarcoma	P53, BAK	[140]
miR-522	↓	Colon	ABCB5	[141]
miR-101	↓	Colon	SphK1	[142]
miR-195	↓	Colon	Bcl-w	[143]
miR-103/107	↓	Gastric	Cav–1	[144]
miR-508–5p	↓	Gastric	ABCB1, ZNRD1	[145]
miR-331–5p	↓	Leukemia	MDR1	[146]
miR-27a	↓	Leukemia	MDR1	[146]

DHFR: Dihydrofolate reductase; TS: Thymididylate synthase; Cav–1: Caveolin–1; SCC: Squamous cell carcinoma; HNSCC: Head and neck SCC.