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. 2016 Mar 15;6:23047. doi: 10.1038/srep23047

Figure 5. Mechanical signatures in multipotent human cells.

Figure 5

(a) Representative microscopy of three distinct multipotent cell types (hASCs, hMSCs and hiPSCs) mechanically characterized by pnCSK microrheology (blue: 1-μm diameter AlexaFluor 633-tagged beads, green: SYTO13 nuclear dye). (b) Differential pnCSK mechanics among multipotent cell types shown by geometric and rheological parameters. (c) Discriminant analysis of multipotent cell types via pnCSK mechanical characterization. Error bars depict the mean ± s.e.m interval (parameter effect significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). Groups not sharing letters within a parameter are statistically significant (paired Tukey-Kramer post hoc: α < 0.05, >90% power). Receiver operating characteristic (ROC) curves and 50% density ellipses are specific to each independent group.