Table 2. NLR (A), RLR (B), cytoplasmic DNA-sensing (C) pathway components, and other inflammasome-related genes (D) that show upregulation in lesions (GW-PLvsPN).
| Symbol | Gene name | FC | FDR | A | B | C | D | MitsuiFC18 | Li FC9 |
|---|---|---|---|---|---|---|---|---|---|
| AIM2 | absent in melanoma 2 | 4.6E + 08 | 0.00 | x | 6.4 | ||||
| ATG5 | autophagy related 5 | 5.3 | 4.19 | x | 0.9 | ||||
| AZI2 | 5-azacytidine induced 2 | 1.5 | 0.50 | x | 1.2 | ||||
| BIRC3 | baculoviral IAP repeat containing 3 | 2.8 | 1.76 | x | 2.4 | ||||
| CAMP | cathelicidin antimicrobial peptide | 5.6E + 09 | 0.00 | x | x | 7.7 | |||
| CARD6 | caspase recruitment domain family, member 6 | 1.0E + 09 | 0.00 | x | 3.3 | ||||
| CARD18 | caspase recruitment domain family, member 18 | 1.1E + 09 | 0.34 | x | 1.3 | ||||
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | 3.0 | 0.00 | x | x | 2.4 | 1.5 | ||
| CASP5 | caspase 5, apoptosis-related cysteine peptidase | 7.6E + 08 | 0.00 | x | 9.8 | ||||
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 3.1 | 2.74 | x | x | 1.5 | |||
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2.5 | 0.41 | x | 1.6 | ||||
| CCL4 | chemokine ligand 4 | 2.2E + 09 | 0.00 | x | 5.3 | ||||
| CXCL1 | chemokine ligand 1 | 5.6E + 08 | 0.00 | x | 8.0 | 70.6 | |||
| CYLD | cylindromatosis (turban tumor syndrome) | 2.2 | 2.89 | x | 3.3 | 1.2 | |||
| DDX3X | DEAD box polypeptide 3, X-linked | 1.7 | 1.74 | x | 2.6 | 1.1 | |||
| DDX58 | DEAD box polypeptide 58 | 3.0 | 0.23 | x | x | x | 2.9 | 2.5 | |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), 1 | 2.0 | 4.98 | x | 1.1 | ||||
| IFI16 | interferon, gamma-inducible protein 16 | 2.4 | 0.23 | x | x | 2.4 | |||
| IFIH1 | interferon induced with helicase C domain 1 | 4.3E + 08 | 0.26 | x | 2.8 | ||||
| IKBKE | inhibitor of k light pp enhancer in Bcells, kinase e | 1.9 | 0.57 | x | x | 2.0 | |||
| IL1B | interleukin 1, beta | 1.1E + 09 | 0.00 | x | x | 6.8 | |||
| IL8 | interleukin 8 | 7.3E + 09 | 0.00 | x | x | 7.4 | 344.2 | ||
| IRF7 | interferon regulatory factor 7 | 2.3E + 08 | 1.65 | x | x | 2.8 | 5.4 | ||
| ISG15 | ISG15 ubiquitin-like modifier | 7.2 | 0.00 | x | 4.4 | 5.5 | |||
| MAPK8 | mitogen-activated protein kinase 8 | 7.2E + 08 | 0.07 | x | x | 1.1 | |||
| MAPK13 | mitogen-activated protein kinase 13 | 2.9 | 0.23 | x | x | 2.4 | 1.5 | ||
| NLRP10 | NLR family, pyrin domain containing 10 | 3.5 | 0.96 | x | x | NA | |||
| NLRX1 | NLR family member X1 | 5.9 | 0.00 | x | x | 2.5 | 2.2 | ||
| NOD2 | nucleotide-binding oligomerization domain containing 2 | 6.0 | 0.00 | x | 3.4 | 3.1 | |||
| 4.3E + 08 | 0.75 | x | |||||||
| POLR3B | polymerase (RNA) III polypeptide B | 2.3 | 1.30 | x | 1.3 | ||||
| POLR3G | polymerase (RNA) III polypeptide G (32kD) | 5.7 | 0.00 | x | 2.8 | 4.3 | |||
| PYCARD | PYD and CARD domain containing | 4.1 | 1.98 | x | x | 2.1 | 2.0 | ||
| 3.0 | 0.31 | x | x | ||||||
| PYDC1 | PYD (pyrin domain) containing 1 | 3.6 | 0.16 | x | 2.0 | ||||
| SUGT1 | SGT1, suppressor of G2 allele of SKP1 | 1.6 | 0.42 | x | 1.2 | ||||
| TAB1 | TGF-b activated kinase 1/MAP3K7 binding prot 1 | 1.60 | 4.67 | x | 0.8 | ||||
| TANK | TRAF family member-associated NFKB activator | 1.73 | 0.16 | x | 2.1 | 1.0 | |||
| TRIM25 | tripartite motif containing 25 | 2.61 | 0.75 | x | 1.6 |
Abbreviations: TFE, Transcript First Exon; FC, Fold Change; FDR, False Discovery Rate (%).