Table 1. Summary of patients demography, main clinical profile, level of severity/impairment, genetics data, treatment duration and response.

Patient	Current age	Age of onset	Core Symptoms	Neuroimaging pattern	Clinical self accessment	Genetic analysis (Gene/mutation)	Treatment duration/follow up
1	57 (deceased)	46	Severe motor and language impairment	Large calcifications in cerebellum, thalamus, basal ganglia and white matter	Stable	PDGFB c.356 T > C	3 months
2	49	44	Moderate Parkinsonism	Large calcifications in cerebellum and basal ganglia	Gradual impairment	NA	9 months
3	48	29	Parkinsonism Depression	Large calcification in thalamus and basal ganglia	Gradual impairment	SLC20A2 c.1483G > A	24 months
4*	85	80	Depression	Large calcificiation in cerebellum and basal ganglia	Symptoms stability	SLC20A2 c.1483G > A	120 months
5	38	37	Headaches Right arm tremor	Moderate calcification in basal ganglia	Decrease in arm paresis and tremor	SLC20A2 c.1753G > A	5 months
6*	51	36	Headaches	Small calcifications in basal ganglia	Symptoms stability	NA	28 months
7	41	38	Headaches	Large calcification in basal ganglia and smaller lesion in thalamus, white matter and cerebellum	Remarkable decrease in number of episodes.	NA	20 months

For comparative reasons, the patients will be presented orderly, from the most critical (Up row) to the most functional one (bottom row), in terms of personal impairment. NA = Not available. *patients with retrospective data.