Figure 2. Longitudinal determination of CD4⁺ T-cell counts and viral load (VL) of HIV-infected SP subgroups.

(a) Frequency of EC, VC and NVC subjects with statistically significant negative slopes for CD4 decline and increased VL calculated on the total number of visits since infection (shown in Table 3). (b) CD4 counts (Upper panels) and Log₁₀ VL (Lower panels) in EC (n = 17), VC (n = 25) and NVC (n = 11) at two clinic visits, V1 (all subjects having CD4 counts ≥ 500 CD4⁺ T-cells/mm³ and VL that corresponds to criteria used to classify each of the subgroups) and V2 (an average time interval from V1 of 30 ± 16, 34 ± 25 and 33 ± 15 months for EC, VC and NVC, respectively). (c) CD4 counts (Left panel) and Log₁₀ VL (Middle panel) at V1 and V2 for SP subjects who lost HIV control (CD4 count decrease of ≥100 cells/mm³ combined with any increase in Log₁₀ VL). Right panel: Frequencies of EC, VC and NVC subjects losing control between V1 and V2 (EC n = 2/17, VC n = 8/25, and NVC n = 7/11). P values were calculated by non-parametric paired two-tail test (Wilcoxon) in B and C. EC = Elite Controller; VC = Virologic Controllers; NVC = Non Virologic Controllers.