Table 2.
Conditional logistic regression: odds ratios (OR) and 95% confidence intervals (CI) for seropositivity to H. pylori antigens and risk of gastric adenocarcinoma and cardia and non-cardia adenocarcinomas subsites.
| All Gastric adenocarcinoma | Gastric cardia adenocarcinoma | Gastric non-cardia adenocarcinoma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | Controls N (%) |
Unadjusted OR (95%CI) |
Adjusted1 OR (95%CI) |
N (%) | Controls N (%) |
Unadjusted OR (95%CI) |
Adjusted1 OR (95%CI) |
N (%) | Controls N (%) |
Unadjusted OR (95%CI) |
Adjusted1 OR (95%CI) |
||
| 272 | 524 | 142 | 276 | 103 | 195 | ||||||||
| Whole cell ELISA | Neg. | 18 (6.6) | 43 (8.2) | 1 | 1 | 11 (7.7) | 20 (7.2) | 1 | 1 | 6 (5.8) | 19 (9.7) | 1 | 1 |
| Pos. | 254 (93.4) | 481 (91.8) | 1.2 (0.7–2.2) | 1.5 (0.8–2.8) | 131 (92.3) | 131 (92.8) | 0.9 (0.4–1.9) | 1.3 (0.5–3.1) | 97 (94.2) | 176 (90.3) | 1.7 (0.6–4.3) | 1.3 (0.4–3.7) | |
| H.pylori Multiplex | Neg. | 13 (4.8) | 28 (5.3) | 1 | 1 | 7 (4.9) | 17 (6.2) | 1 | 1 | 5 (4.9) | 8 (4.1) | 1 | 1 |
| Pos. | 259 (95.2) | 496 (94.7) | 1.1 (0.5–2.3) | 1.4 (0.6–3.1) | 135 (95.1) | 259 (93.8) | 1.2 (0.5–3.2) | 1.7 (0.6–4.8) | 98 (95.1) | 187 (95.9) | 0.8 (0.2–2.7) | 0.7 (0.2–2.7) | |
| GroEL | Neg. | 59 (21.7) | 73 (13.9) | 1 | 1 | 22 (15.5) | 34 (12.3) | 1 | 1 | 32 (31.1) | 35 (18.0) | 1 | 1 |
| Pos. | 213 (78.3) | 451 (86.1) | 0.5 (0.3–0.8) | 0.6 (0.4–0.9) | 120 (84.5) | 242 (87.7) | 0.7 (0.4–1.3) | 0.8 (0.4–1.5) | 71 (68.9) | 160 (82.1) | 0.4 (0.2–0.8) | 0.4 (0.2–0.9) | |
| UreA | Neg. | 139 (51.1) | 236 (45.0) | 1 | 1 | 72 (50.7) | 115 (41.7) | 1 | 1 | 55 (53.4) | 96 (49.2) | 1 | 1 |
| Pos. | 133 (48.9) | 288 (55.0) | 0.7 (0.5–1.1) | 0.8 (0.5–1.1) | 70 (49.3) | 161 (58.3) | 0.6 (0.4–1.1) | 0.6 (0.3–1.1) | 48 (46.6) | 99 (50.8) | 0.8 (0.5–1.4) | 0.8 (0.5–1.5) | |
| HP0231 | Neg. | 140 (51.5) | 237 (45.2) | 1 | 1 | 72 (50.7) | 134 (48.6) | 1 | 1 | 55 (53.4) | 81 (41.5) | 1 | 1 |
| Pos. | 132 (48.5) | 287 (54.8) | 0.7 (0.5–1.1) | 0.8 (0.6–1.2) | 70 (49.3) | 142 (51.5) | 0.8 (0.5–1.3) | 0.9 (0.6–1.4) | 48 (46.6) | 114 (58.5) | 0.6 (0.3–1.1) | 0.7 (0.4–1.2) | |
| NapA | Neg. | 129 (47.4) | 175 (33.4) | 1 | 1 | 57 (40.1) | 90 (32.6) | 1 | 1 | 60 (58.3) | 76 (39.0) | 1 | 1 |
| Pos. | 143 (52.6) | 349 (66.6) | 0.5 (0.3–0.7) | 0.6 (0.4–0.8) | 85 (59.9) | 186 (67.4) | 0.7 (0.4–1.1) | 0.8 (0.5–1.3) | 43 (41.8) | 119 (61.0) | 0.4 (0.2–0.7) | 0.4 (0.2–0.8) | |
| HP0305 | Neg. | 128 (47.1) | 242 (46.2) | 1 | 1 | 69 (48.6) | 125 (45.3) | 1 | 1 | 47 (45.6) | 100 (51.3) | 1 | 1 |
| Pos. | 144 (52.9) | 282 (53.8) | 0.9 (0.7–1.3) | 1.1 (0.7–1.4) | 73 (51.4) | 151 (54.7) | 0.8 (0.5–1.3) | 0.9 (0.5–1.4) | 56 (54.4) | 95 (48.7) | 1.2 (0.7–2.1) | 1.3 (0.7–2.2) | |
| HpaA | Neg. | 204 (75.0) | 355 (67.8) | 1 | 1 | 108 (76.1) | 193 (69.9) | 1 | 1 | 74 (71.8) | 126 (64.6) | 1 | 1 |
| Pos. | 68 (25.0) | 169 (32.3) | 0.6 (0.4–0.9) | 0.7 (0.5–1.1) | 34 (23.9) | 83 (30.1) | 0.7 (0.4–1.1) | 0.6 (0.4–1.1) | 29 (28.2) | 69 (35.4) | 0.6 (0.3–1.1) | 0.9 (0.4–1.7) | |
| Cagδ | Neg. | 96 (35.3) | 223 (42.6) | 1 | 1 | 49 (34.5) | 112 (40.6) | 1 | 1 | 38 (36.9) | 88 (45.1) | 1 | 1 |
| Pos. | 176 (64.7) | 301 (57.4) | 1.3 (1.1–1.8) | 1.3 (0.9–1.9) | 93 (65.5) | 164 (59.4) | 1.3 (0.8–2.1) | 1.5 (0.9–2.4) | 65 (63.1) | 107 (54.9) | 1.3 (0.8–2.2) | 1.2 (0.7–2.1) | |
| CagM | Neg. | 103 (37.9) | 227 (43.3) | 1 | 1 | 55 (38.7) | 116 (42.0) | 1 | 1 | 40 (38.8) | 87 (44.6) | 1 | 1 |
| Pos. | 169 (62.1) | 297 (56.7) | 1.2 (0.9–1.7) | 1.1 (0.8–1.6) | 87 (61.3) | 160 (58.0) | 1.1 (0.7–1.8) | 1.1 (0.6–1.6) | 63 (61.2) | 108 (55.4) | 1.2 (0.7-–2.1) | 1.3 (0.7–2.3) | |
| CagA | Neg. | 28 (10.3) | 115 (22.0) | 1 | 1 | 17 (12.0) | 56 (20.3) | 1 | 1 | 9 (8.7) | 47 (24.1) | 1 | 1 |
| Pos. | 244 (89.7) | 409 (78.1) | 2.4 (1.5–3.7) | 2.6 (1.6–4.2) | 125 (88.0) | 220 (79.7) | 1.9 (1.1–3.4) | 2.1 (1.1–4.1) | 94 (91.3) | 148 (75.9) | 3.1 (1.4–6.5) | 3.5 (1.4–8.2) | |
| HyuA | Neg. | 113 (41.5) | 205 (39.1) | 1 | 1 | 59 (41.6) | 98 (35.5) | 1 | 1 | 43 (41.8) | 81 (41.5) | 1 | 1 |
| Pos. | 159 (58.5) | 319 (60.9) | 0.9 (0.6–1.2) | 0.8 (0.6–1.1) | 83 (58.5) | 178 (64.5) | 0.7 (0.4–1.1) | 0.6 (0.4–1) | 60 (58.3) | 114 (58.5) | 1.1 (0.6–1.6) | 0.9 (0.5–1.6) | |
| Catalase | Neg. | 125 (46.0) | 263 (50.2) | 1 | 1 | 63 (44.4) | 143 (51.8) | 1 | 1 | 47 (45.6) | 89 (45.6) | 1 | 1 |
| Pos. | 147 (54.0) | 261 (49.8) | 1.2 (0.8–1.6) | 1.1 (0.7–1.5) | 79 (55.6) | 133 (48.2) | 1.4 (0.9–2.1) | 1.2 (0.7–1.9) | 56 (54.4) | 106 (54.4) | 0.9 (0.5–1.6) | 0.8 (0.4–1.6) | |
| VacA | Neg. | 65 (23.9) | 180 (34.4) | 1 | 1 | 39 (27.5) | 84 (30.4) | 1 | 1 | 21 (20.4) | 74 (38.0) | 1 | 1 |
| Pos. | 207 (76.1) | 344 (65.7) | 1.6 (1.1–2.3) | 1.7 (1.1–2.5) | 103 (72.5) | 192 (69.6) | 1.1 (0.7–1.8) | 1.1 (0.7–1.9) | 82 (79.6) | 121 (62.1) | 2.4 (1.3–4.4) | 2.7 (1.4–5.2) | |
| HcpC | Neg. | 170 (62.5) | 307 (58.6) | 1 | 1 | 90 (63.4) | 159 (57.6) | 1 | 1 | 65 (63.1) | 117 (60.0) | 1 | 1 |
| Pos. | 102 (37.5) | 217 (41.4) | 0.8 (0.6–1.1) | 0.9 (0.7–1.3) | 52 (36.6) | 117 (42.4) | 0.7 (0.5–1.1) | 0.8 (0.5–1.3) | 38 (36.9) | 78 (40.0) | 0.8 (0.5–1.4) | 1.1 (0.6–1.8) | |
| Cad | Neg. | 140 (51.5) | 289 (55.2) | 1 | 1 | 77 (54.2) | 162 (58.7) | 1 | 1 | 53 (51.5) | 100 (51.3) | 1 | 1 |
| Pos. | 132 (48.5) | 235 (44.9) | 1.1 (0.8–1.5) | 1.3 (0.9–1.7) | 65 (45.8) | 114 (41.3) | 1.1 (0.7–1.8) | 1.2 (0.8–1.9) | 50 (48.5) | 95 (48.7) | 1.1 (0.6–1.6) | 1.1 (0.6–1.9) | |
| Omp | Neg. | 48 (17.7) | 91 (17.4) | 1 | 1 | 27 (19.0) | 47 (17.0) | 1 | 1 | 18 (17.5) | 30 (15.4) | 1 | 1 |
| Pos. | 224 (82.4) | 433 (82.6) | 0.9 (0.6–1.4) | 0.9 (0.6–1.5) | 115 (81.0) | 229 (83.0) | 0.8 (0.4–1.4) | 0.8 (0.4–1.5) | 85 (82.5) | 165 (84.6) | 0.8 (0.4–1.6) | 0.7 (0.3–1.6) | |
1
Adjusted for education (illiterate vs. otherwise), ethnicity (Turkmen vs. non-Turkmen), tobacco and opium consumption (ever vs. never), and wealth score as continuous variable