Table 5.
Association of seropositivity to H. pylori antigens and non-cardia adenocarcinoma in different populations.
| Study area/ design | Adjusted OR (95% CI) | Others antigens with significant associations | |||
|---|---|---|---|---|---|
| CagA | VacA | GroEL | NapA | ||
| 1Iran/Case-control (present study) | 3.5 (1.4–8.2) | 2.7 (1.4–5.2) | 0.4 (0.2–0.9) | 0.4 (0.2–0.8) | None |
| 2China, Shanghai/Nested Case-control(17) | 3.3 (1.1–10.1) | 2.1 (1.2–3.8) | 1.2 (0.7–2.1) | 1.3 (0.8–1.9) | Omp, HP0305,HpaA |
| 3Germany/Case-control(18) | 5.6 (3.2–9.9) | 2.1 (1.3–3.5) | 4.6 (2.5–8.5) | 1.4 (0.9–2.2) | HcpC,Catalase,HP0305, Cagδ, HyuA |
| 4Sweden/Case-control(16) | 9.2 (5.3–15.8) | 3.5 (2.3–5.5) | 6.6 (3.7–11.7) | 3.4 (2.1–5.4) | All others except HP0305 |
| 5China, Linxian /cohort(19) | 2.1 (1.4–2.8) | 1.9 (1.3–2.7) | 1.5 (1.1–2.1) | 1.1 (0.8–1.4) | HcpC and HP0305; only Cag M had inverse association |
Adjusted for:
1
education, ethnicity, tobacco and opium consumption, and wealth score.
2
age, date and time of sample collection; time interval since last meal and antibiotic use in the past week.
3
age, sex, education, family history of gastric cancer, smoking, and alcohol drinking.
4
age, sex, area of residence, SES, use of tobacco, level of fruit and vegetable consumption, and number of siblings.
5
age at blood draw, sex, ever smoking, alcohol and BMI.