Table 1.
Dose fractionation schedules, biologically effective dose, and dose-volume constraints
Dose and no. of fractions | Biologically effective dose (Gy) |
No. of patients | Average stomach V50 (cm3) or maximum point dose if V50 = 0 cm3 |
Average duodenum V50 (cm3) or maximum point dose if V50 = 0 cm3 |
---|---|---|---|---|
63 Gy in 28 fx | 77.2 | 14 | 25.5 | 22.8 |
70 Gy in 28 fx | 87.5 | 11 | 25 | 27.6 |
67.5 Gy in 15 fx | 97.9 | 7 | 0; 44.8 Gy | 0; 44.9 Gy |
60 Gy in 10 fx | 96.0 | 1 | 0; 41.3 Gy | 0; 43 Gy |
50 Gy in 5 fx | 100.0 | 1 | 0; 26.3 Gy | 0; 36.1 |
51.3–70.4 Gy in 13–39 fx | 70.4–84.3 | 13 | 33.9 | 15.2 |
Abbreviations: fx = fractions; V50 = volume of organ receiving >50 Gy.
α/β = 10 for calculation of biologically effective dose.