Figure 3.

Four representative pathologic GRα mutants change conformational and chemical properties of their LBP. LBP of the wild-type GRα (A) and 4 representative pathologic GRα mutants (I559N, ligand-binding defective; V575G, AF-2 defective; G679S and I747M, both defective) (B) are shown. Positive and negative electrostatic potential are indicated with blue and red, respectively. The key residues of the receptors making important molecular interactions to dexamethasone are incorporated. The structures shown and their calculated biochemical properties are those of the averaged trajectories. DEX, dexamethasone; WT, wild type.