Table 1.
Comparison of serum oxidative stress parameters and antioxidant status
| Group | MDA (nmol/mL) | SOD (U/mg protein) | CAT (k/g protein) | GPX (U/mg protein) | GSH (μmol/L) | TOS (μmol H2O2 equivalent/L) | TAC (Trolox equivalent/L) | OSI (arbitrary unit) |
|---|---|---|---|---|---|---|---|---|
| Control (K) | 1.53 (1.08–1.97)† | 24.6 (19.4–30.6)† | 1.79 (0.81–2.26)† | 7.55 (5.8–9.5)† | 0.34 (0.24–058) | 4.57 (3.8–4.9)† | 1.21 (0.82–1.25)† | 0.40 (0.31–0.54)† |
| Dexpanthenol (D) | 1.43 (0.89–1.77)† | 27.4 (20.0–38.9)† | 1.70 (1.18–2.62)† | 6.40 (5.6–7.6) | 0.31 (0.29–0.50) | 4.26 (2.6–6.7)† | 1.08 (0.78–1.35) | 0.38 (0.24–0.72)† |
| Cisplatin (C) | 2.17 (1.38–2.87)* | 13.1 (11.3–18.7)* | 1.11 (0.81–1.48)* | 5.78 (1.4–7.2)* | 0.26 (0.12–0.47) | 9.30 (7.3–10.3)* | 0.89 (0.75–1.20)* | 1.08 (0.75–1.24)* |
| Cisplatin+Dexpanthenol (CD) | 1.58 (1.07–1.97)† | 24.2 (11.7–33.7)† | 1.77 (1.04–2.23)† | 7.5 (5.5–8.1)† | 0.33 (0.23–0.58) | 3.78 (3.6–6.5)† | 1.17 (1.06–1.35)† | 0.31 (0.27–0.61)† |
Values are presented as median (range).
MDA, malondialdehyde; SOD, superoxide dismutase; CAT, catalase; GPX, glutathione peroxidase; GSH, glutathione; TOS, total oxidant status; TAC, mean total antioxidant status; OSI, oxidative stress index.
*
P<0.05 vs. K group.
†
P<0.05 vs. C group.