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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Vaccine. 2012 Feb 11;30(15):2516–2522. doi: 10.1016/j.vaccine.2012.01.090

Table 2.

HA and NA antibody response and cross-reactivity in LAIV immunized ferrets

Geometric mean serum NI titers of ferrets
immunized with 1 dose of LAIV
Test antigen* NC99
H1N1		 SD07
H1N1		 HK03
H5N1		 CA09
pH1N1
NC99 32 20 <8 <8
SD07 8 128 <8 <8
HK03 <8 <8 161 13
CA09 <8 <8 40 512
Geometric mean serum HAI titers of ferrets
immunized with 1 dose of LAIV
Test antigen NC99
H1N1		 SD07
H1N1		 HK03
H5N1		 CA09
pH1N1
NC99 203 32 <8 <8
SD07 25 256 <8 <8
HK03 <8 <8 102 <8
CA09 <8 <8 <8 645
*

Reassortant H6 viruses bearing the NA from the indicated virus.

Groups of three ferrets were inoculated intranasally with 107 FFU/ml of the indicated LAIV viruses. Serum was collected 2 to 3 weeks after immunization. The NI titers were determined by NI assay against the H6 reassortants containing the indicated NA test antigen. The HAI titers were determined by HAI assay using turkey RBC and the indicated viruses.