TABLE 1.
Serum neutralizing antibodies elicited in mice following intranasal infection with H1N1 viruses
| Serum neutralizing antibody response against indicated virus |
||||||
|---|---|---|---|---|---|---|
| Primary infectiona | CA/7/09 | NJ/76 | sw/IA/31 | |||
| GMT (range)b | # with detectable antibody/totalc | GMT (range) | # with detectable antibody/total | GMT (range) | # with detectable antibody/total | |
| CA/7/09 | 1280d | 2/2 | NDe | NDe | ||
| CA/4/09 | 446 (320-806) | 8/8 | NDe | NDe | ||
| NJ/76 | 34 (10-63) | 7/8 | 58 (20-113) | 8/8 | 16 (10-25) | 3/8 |
| sw/IA/31 | 41 (10-101) | 7/8 | 29 (16-57) | 8/8 | 281 (202-403) | 8/8 |
a
Mice received 105 TCID50 of indicated virus i.n. and serum was obtained on day 25 p.i..
b
Values represent geometric mean antibody titers from 2-8 mice per group. Antibodies were not detectable in pre-infection sera. Homologous antibody titers are in bold. An undetectable serum neutralizing antibody titer was assigned a value of 10.
c
Numbers of mice elicited neutralizing antibody response from each group are indicated.
d
Serum neutralizing antibody titer in two of the eight mice in the group that survived following primary infection with CA/7/09.
e
ND: Not determined.