TABLE 2.
Serum neutralizing and HAI antibodies elicited in ferrets following intranasal infection with H1N1 viruses
| Primary infectiona | Geometric mean (range) serum neutralizing antibody titers against indicated virusb |
Geometric mean (range) serum HAI antibody titers against indicated virusc |
||||
|---|---|---|---|---|---|---|
| CA/7/09 | NJ/76 | sw/IA/31 | CA/7/09 | NJ/76 | sw/IA/31 | |
| CA/7/09 | 1140 (254-5120) | 2560 (2032-3225) | 10 | 320 | 113 (80-160) | 5 |
| CA/4/09 | 2370 (1810-4064) | 941(508-1613) | 10 | 403 (320-640) | 80 (40-160) | 5 |
| NJ/76 | 436 (320-806) | 2463 (1613-3620) | 10 | 80 (40-160) | 127 (80-160) | 5 |
| sw/IA/31 | 37 (32-40) | 1881 (1016-4064) | 1280 (1016-2032) | 8 (5-20) | 64 (40-160) | 101 (40-320) |
a
Ferrets received 106 TCID50 of the virus i.n. and serum was obtained four weeks later. Values represent geometric mean antibody titers from three ferrets per group. Antibodies were not detectable in pre-infection sera. Homologous antibody titers are in bold. Ranges of of antibody titers are in parentheses.
b
An undetectable serum neutralizing antibody titer was assigned a value of 10.
c
An undetectable HAI antibody titer was assigned a value of 5.