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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Am J Transplant. 2015 Apr 6;15(9):2404–2412. doi: 10.1111/ajt.13271

Figure 2. Effect of microvesicles derived from human mesenchymal stem cells on alveolar fluid clearance in donor human lungs rejected for transplantation.

Figure 2

Administration of MSC MV significantly improved AFC in a dose-dependent manner compared to the Control (Perfusion only) at T6. Administration of NHLF MV as a cellular control had no effect on AFC compared to the Control at T6. Inhibition of CD44 with a neutralizing Ab significantly reduced the therapeutic effect of MSC MV 200 μL, whereas administration of IgG control with MSC MV 200 μL had no significant effect. Data are presented as mean ± SD, N = 4-6 per group. *p significant by ANOVA vs. T0, †p significant by ANOVA versus T6 Perfusion Only, ‡p significant by ANOVA versus T6 MSC MV 200 μL. Abbreviations: Ab, antibody; AFC, alveolar fluid clearance; MSC, mesenchymal stem cells; MV, microvesicles; NHLF, normal human lung fibroblast.