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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Am J Transplant. 2015 Apr 6;15(9):2404–2412. doi: 10.1111/ajt.13271

Figure 7. Role of CD44 in MSC MV uptake into primary cultures of human alveolar epithelial type 2 cells.

Figure 7

In human alveolar epithelial type 2 cells, MSC MV uptake was dependent on CD44, the cell surface receptor for hyaluronic acid, following injury. Stimulation by an inflammatory injury (cytomix) increased the uptake of fluorescent-labeled MSC MV into alveolar epithelial type 2 cells. Fluorescence intensity was expressed as mean (% of control) ± SD for each condition, N = 179–262 cells for all groups. *p < 10 −4 versus MV/cytomix, ANOVA + †p = 0.001 versus Control Group by (Bonferroni). Photomicrographs display the pattern of fluorescence levels observed in each experimental condition. Scale bar is 20 μm.