Table 1.
Donor clinical data and ischemia time
| Perfusion only |
MSC MV 100 μL |
MSC MV 200 μL |
MSC MV 200 μL + anti-CD44 Ab |
MSC MV 200 μL + IgG |
NHLF MV 200 μL |
|
|---|---|---|---|---|---|---|
| Variable | (n = 6) | (n = 6) | (n = 6) | (n = 4) | (n = 4) | (n = 4) |
| Mean age (year) | 57 ± 8 | 49 ± 11 | 43 ± 16 | 56 ± 9 | 57 ± 9 | 46 ± 18 |
| Male (%) | 33 | 67 | 67 | 75 | 50 | 25 |
| Chest radiograph infiltrates | 2 ± 0 | 2 ± 1 | 2 ± 1 | 2 ± 1 | 2 ± 1 | 2 ± 2 |
| Donor PaO2/FiO2 ratio (mmHg) | 259 ± 107 | 275 ± 155 | 294 ± 137 | 309 ± 102 | 270 ± 142 | 414 ± 73 |
| PEEP (cmH2O) | 8 ± 3 | 6 ± 2 | 8 ± 4 | 8 ± 2 | 7 ± 2 | 6 ± 2 |
| Donor lung compliance (ml/cmH2O) | 35.6 ± 4.9 | 40.5 ± 10.1 | 34.0 ± 11.2 | 36.8 ± 7.6 | 41.6 ± 13.3 | 35.5 ± 14.8 |
| Lung injury score | 1.75 ± 0.40 | 1.71 ± 0.90 | 1.75 ± 0.97 | 1.69 ± 0.52 | 1.63 ± 0.48 | 1.44 ± 0.31 |
| Ischemic time (hours:minutes) | 21:26 ± 10:29 | 20:35 ± 16:40 | 28:01 ± 11:03 | 33:26 ± 4:16 | 27:25 ± 16:35 | 34:55 ± 8:36 |
Ab, antibody; MSC MV, microvesicles derived from mesenchymal stem cells; NHLF MV, microvesicles derived from normal human lung fibroblasts; PEEP, positive end-expiratory airway pressure.
Data are expressed as mean ± SD.
Lung Injury Score based on maximum of 4 points for the PaO2/FiO2 ratio, the level of positive end-expiratory airway pressure, the quasi-static respiratory compliance and the extent of chest radiograph infiltrates.