Table 2.
Role of unfolded protein response genes in physiological development
| Gene name | Embryonic lethal knockout? | Developmental process |
|---|---|---|
| IREα | Yes | Immune cell differentiation, hepatogenesis, chondrogenesis, adipogenesis |
| IRE1β | No | |
| XBP-1 | Yes | Immune cell differentiation, hepatogenesis, zymogen cell differentiation, adipogenesis |
| ATF6α/β | Individual KO of α or β—No Double α/βKO—Yes | Neurogenesis, hepatogenesis |
| PERK | No | Pancreatic β-cell differentiation, osteogenesis |
| ATF4 | Yes | Osteogenesis, lens formation, hematopoiesis |
| BiP | Yes | Early development, neurogenesis |