Skip to main content
. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Expert Rev Mol Med. 2010 Nov 1;12:e35. doi: 10.1017/S1462399410001675

Figure 3. Representative proteomic profiles characteristic for intra-amniotic inflammation and bleeding.

Figure 3

Three hypervariable areas of representative surface-enhanced laser desorption ionisation time-of-flight tracings of amniotic fluid from women admitted for preterm birth are shown: (a) 3–4 kDa, (b) 10–12.5 kDa and (c) 14–17 kDa. These areas contain proteomic patterns characteristic of intra-amniotic inflammation (MR score composed of four protein biomarkers – P1, P2, P3 and P4) (Ref. 79), intra-amniotic bleeding (Hb chains) or both (bottom tracings). The x-axis of the tracings represents the molecular mass in daltons; the y-axis represents the normalised peak intensity. R denotes a reference protein peak present in all fluid samples, which corresponds to a fragment of beta-2 microglobulin (originally published in Ref. 80; reproduction permitted under Creative Commons Attribution License). Abbreviations: Hb, haemoglobin; MR, mass-restricted; P1, neutrophil defensin-2; P2, neutrophil defensin-1; P3, calgranulin C; and P4, calgranulin A.