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. Author manuscript; available in PMC: 2017 Mar 28.
Published in final edited form as: Cancer Lett. 2016 Jan 18;372(2):179–186. doi: 10.1016/j.canlet.2016.01.018

Fig. 1.

Fig. 1

Effect of entrectinib on TrkB phosphorylation in SY5Y-TrkB cells (clone BR6). A. Cells were exposed to BDNF in the presence or absence of increasing concentrations of entrectinib. Substantial inhibition of phosphorylation was observed at as low as 1nM concentration of entrectinib. Inhibition of Akt phosphorylation was also observed with increasing concentrations of entrectinib. Pan-Trk, Akt, pMAPK and actin showed no effect of inhibition. B. Growth profile of SY5Y-TrkB cells. Representative SRB assay indicating dose dependent inhibition of SY5Y-TrkB cells upon entrectinib treatment as indicated. Each assay was performed in triplicate, and at least three independent experiments were conducted.