Skip to main content
. Author manuscript; available in PMC: 2017 Mar 28.
Published in final edited form as: Cancer Lett. 2016 Jan 18;372(2):179–186. doi: 10.1016/j.canlet.2016.01.018

Fig. 2.

Fig. 2

Effect of entrectinib on TrkB phosphorylation in NLF-TrkB cells. A. Western blot analysis of NLF-TrkB upon entrectinib treatment. Cells were exposed to BDNF in the presence or absence of increasing concentrations of entrectinib. Substantial inhibition of phosphorylation was observed at as low as 50 nM concentration of entrectinib. Inhibition of Akt phosphorylation was also seen with increasing concentrations of entrectinib. B. Growth profile of NLF-TrkB cells. Representative SRB assay indicating dose-dependent inhibition of NLF-TrkB cells (clone 6) upon entrectinib treatment. Each assay was performed in triplicate, and at least three independent experiments were conducted.