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. Author manuscript; available in PMC: 2017 Mar 28.
Published in final edited form as: Cancer Lett. 2016 Jan 18;372(2):179–186. doi: 10.1016/j.canlet.2016.01.018

Fig. 3.

Fig. 3

Effect of entrectinib on the growth of SY5Y-TrkB (BR6) xenografts. A. Growth pattern of SY5Y-TrkB xenografts. Entrectinib significantly decreases the growth of SY5Y-TrkB cells grown as xenografts in athymic nu/nu mice (p<0.0001). B. Kaplan-Meier survival curves of SY5Y-TrkB xenografts. Significantly prolonged EFS was also observed in the entrectinib treated group compared to control (p<0.0001). C. Western blot analysis of tumor samples at various times. Analysis of tumor samples shows inhibition of p-TrkB, p-PLCγ, p-Akt and p-Erk in tumors of animals treated with entrectinib. The control group showed no significant inhibition.