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Effect of entrectinib in combination with Irino-TMZ on SY5Y-TrkB xenograft growth. A. Growth pattern of SY5Y-TrkB xenografts. Significant inhibition of tumor growth was observed in the entrectinib (single agent or combination with Irino-TMZ) compared to control or Irino-TMZ group. B. Kaplan-Meier survival curves of SY5Y-TrkB xenografts. Statistically significant differences in EFS were observed in the combination treated groups compared to Irino-TMZ alone.
