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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Chem Rev. 2016 Feb 11;116(5):3436–3486. doi: 10.1021/acs.chemrev.5b00597

Figure 3.

Figure 3

The structures of double-stranded DNA adducts of different platinum anticancer agents as determined by X-ray crystallography or NMR spectroscopy. (a) Cisplatin 1,2-d(GpG) intrastrand cross-link (PDB 1AIO). (b) Cisplatin 1,3-d(GpTpG) intrastrand cross-link (PDB 1DA4). (c) Cisplatin interstrand cross-link (PDB 1A2E). (d) Oxaliplatin 1,2-d(GpG) intrastrand cross-link (PDB 1PG9). (e) Satraplatin 1,2-d(GpG) intrastrand cross-link (PDB 1LU5). (f) cDPCP monofunctional adduct (PDB 3CO3). Reproduced from reference 41. Copyright © 2009, The Royal Society of Chemistry.