Table 6.
Genetic defects that cause mendelian susceptibility to mycobacterial diseases.
| Genetic defects | Gene Symbol | Locus | Inheritance | OMIM |
|---|---|---|---|---|
| INTERFERON, GAMMA, RECEPTOR 1 | IFNGR1 | 6q23-24 | Autosomal recessive & dominant | *107470 |
| INTERFERON, GAMMA, RECEPTOR 2 | IFNGR2 | 21q22 | Autosomal recessive | *147569 |
| INTERLEUKIN 12 RECEPTOR, BETA-1 | IL-12RB1 | 19p13 | Autosomal recessive | *601604 |
| INTERLEUKIN 12B or IL12, SUBUNIT p40 | IL12B | 5q31 | Autosomal recessive | *161561 |
| SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 | STAT1 | 2q32 | Autosomal recessive & dominant | *600555 |
| INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE OF, GAMMA or NF-KAPPA-B ESSENTIAL MODULATOR | IKBKG or NEMO | Xq28 | X-linked | *300248 |
| CYTOCHROME b(-245), BETA SUBUNIT | CYBB | Xp11.4 | X-linked | *300481 |
| INTERFERON REGULATORY FACTOR 8 | IRF8 | 16q24.1 | Autosomal dominant | *601565 |