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. 2015 Sep 28;24:170–179. doi: 10.1007/s40629-015-0065-1

Fig. 1.

Fig. 1

Snapshot of dermal dendritic cell clustering and schema of iSALT. a: Cluster formation by dermal dendritic cells and perivascular macrophages was visualized in the ear skin dermis of CD11c YFP mice in the elicitation phase of CHS, with some modification of the ref. 3. Scale bar = 100 um. . b: A schema of inducible skin associated lymphoid tissue (iSALT) in the elicitation phase of CHS. ① = IL-1α secreted from KCs under stimulation by haptens activates perivascular macrophages. ② = Perivascular macrophages secrete chemokine (C-X-C motif) ligand 2 (CXCL2), leading to dDC accumulation that express chemokine (C-X-C motif) receptor 2 (CXCR2). ③ = dDC clustering traps memory T cells at the site of extravasation. This perivascular macrophage-dDC-T cell clustering is considered to be iSALT. ④ = Memory T cells are activated to produce IFN-γ through interaction with dDCs. ⑤ = Epidermal spongiosis (intercellular edema) occurs just above iSALT.