Table 2.
Author | Year | Study type | Level of evidence | Subjects | No. | Patient characteristics | Duration/follow-up | Sleep study | Results (with dentures vs. without dentures) | Conclusion (effects of nocturnal denture wearing) | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age (years) | Gender (M/F) | BMI (kg/m2) | AHI (/h) | Mean SaO2 (%) | Lowest SaO2 (%) | |||||||||
Bucca et al. [11] | 1999 | Case series | 4 | Edentulous OSA patients | N = 6 | 63 ± 4 | M: n = 6 | 31 ± 2 | 2 × 1 night (consecutive) | In-laboratory PSG | 13 ± 4 vs. 20 ± 5 | 92 ± 2 vs. 90 ± 2 | 85 ± 2 vs. 82 ± 2 | (1) Decrease of AHI (2) Increased mean/lowest SaO2 (3) Increase of retropharyngeal space |
Bucca et al. [12] | 2006 | Clinical trial | 2b | Edentulous OSA and non-OSA patients | N = 48 | 69 ± 9 | M: n = 29 F: n = 19 |
28 ± 1 | 2 × 1 night (consecutive) | In-laboratory PSG or ambulatory PSG | 11 ± 2 vs. 17 ± 4 | 93 ± 0 vs. 93 ± 1 | 84 ± 1 vs. 82 ± 1 | (1) Decrease of AHI (2) Increased mean/lowest SaO2 (3) Decreased exhaled eNO (4) Increase of retropharyngeal space |
Almeida et al. [26] | 2012 | Randomized clinical trial | 2b | Edentulous OSA patients, age ≥ 60 years | N = 23 | 70 ± 5 | M: n = 6 F: n = 17 |
27 ± 3 | 2 × 15+ days | In-laboratory PSG | 26 ± 15 vs. 20 ± 10 | NS | NS | (1) Increase of AHI (2) No significant difference in mean/lowest SaO2 |
Arisaka et al. [27] | 2009 | Clinical trial | 2b | Edentulous OSA and non-OSA patients | \N = 34 | 73 ± 9 | M: n = 16 F: n = 18 |
23 ± 4 | 2 × 1 night (consecutive) | Ambulatory PSG | 13 ± 10 vs. 18 ± 15 | NS | NS | (1) Decrease of AHI in 19/27 patients (2) Increase of AHI in 8/27 patients (3) No significant difference in lowest/mean SaO2 |
Data regarding age, BMI, AHI, and mean and lowest hemoglobin oxygen saturation (SaO2) are presented as mean ± standard deviation
AHI apnea–hypopnea index, eNO exhaled nitric oxide (marker for inflammation), NR not reported, NS not significant, OSA obstructive sleep apnea, PSG polysomnography, SaO 2 hemoglobin oxygen saturation