Table 1. Clinical and geographic origins of 24 whole genome sequenced strains.

Strain	# of gene clusters	Clinical origin	Geographic origin	GenBank BioProject	Reference
3655	1991	Blood	San Diego, CA	PRJNA54385	[121]
22.1–21	1967	Nasopharynx	Ann Arbor, MI	PRJNA16398	[122]
22.1–24	1973	Nasopharynx	Ann Arbor, MI	PRJNA29373	[122]
22.4–21	1957	Nasopharynx	Ann Arbor, MI	PRJNA16396	[122]
6P18H1	2015	COPD	Iowa City, Iowa	PRJNA55127	[19]
7P49H1	1897	COPD	Buffalo, NY	PRJNA55129	[19]
86-028NP	2001	Nasopharynx	Nationwide Children’s Hospital, Columbus, OH	PRJNA58093	[115]
B10810	2044	Meningitis	United Kingdom	PRJNA86647	Wellcome Trust Sanger Institute
NML20	1838	Blood	Manitoba, Canada	PRJNA29375	[19]
PittAA	2003	COME, tube replacement	Children’s Hospital, Pittsburgh, PA	PRJNA54391	[123]
PittBB	1922	COME, tube replacement	Children’s Hospital, Pittsburgh, PA	PRJNA16402	[19]
PittCC	1915	COME, tube replacement	Children’s Hospital, Pittsburgh, PA	PRJNA18099	[19]
PittDD	1865	COME, tube replacement	Children’s Hospital, Pittsburgh, PA	PRJNA16392	[19]
PittEE	1848	COME, tube replacement	Children’s Hospital, Pittsburgh, PA	PRJNA58591	[123]
PittGG	1966	AOM, ottorhea	Children’s Hospital, Pittsburgh, PA	PRJNA58593	[123]
PittHH	1948	COME, tube replacement	Children’s Hospital, Pittsburgh, PA	PRJNA54393	[123]
PittII	2057	AOM, ottorhea	Children’s Hospital, Pittsburgh, PA	PRJNA54395	[123]
PittJJ	2054	COME, tube replacement	Children’s Hospital, Pittsburgh, PA	PRJNA18103	[19]
R1838	1900	Blood	Papua New Guinea	PRJNA29377	[19]
R2846	1856	OME	Seattle, WA	PRJNA161921	[124, 125]
R2866	2017	Blood	Seattle, WA	PRJNA161923	[124, 126]
R3021	2017	Nasopharynx	Seattle, WA	PRJNA54397	[124]
R393	2109	Sputum isolate	Malaysia	PRJNA29379	[19]
Rd KW20	1892	Laboratory Strain	Columbia University	PRJNA57771	[127]

COME—Chronic otitis media with effusion; AOM—Acute otitis media; COPD—Chronic obstructive pulmonary disease