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. 2015 Sep 16;3(1):9–18. doi: 10.1002/mdc3.12225

Table 1.

Cognitive outcome measures

Outcome measure Reference for studies used Diagnostic utility Inter‐rater reliability Test‐retest reliability Responsiveness Clinically meaningful change Endorsement
ADAS‐cog 25, 26, 27, 28, 33, 34, 36, and 37 NE High Moderate to high Yes 4 points Recommended
MDRS 23, 31, 32, and 37 High High High Yes NE Recommended
MoCA Not used Moderate High High Yes NE Suggested
CDR 25, 27, and 39 NE NE Moderate Yes NE Suggested
FAB 33 and 34 Moderate High High NE NE Suggested
D‐KEFS VF 25, 26, 27, 34, and 36 Low to moderate NE Moderate to high NE NE Suggested
HVLT 31 High NE NE NE NE Suggested
TPCT 23, 27, and 33 High NE NE NE NE Suggested
MMSE 22, 23, 24, 25, 26, 27, 28, 31, 32, 33, 34, 35, 36, and 37 Low to moderate High High Low for small changes 1.4 points Listed
QTCS 22 NE NE NE NE NE Listed
VMI 31 NE NE NE NE NE Listed
BTA 26 and 31 NE NE NE NE NE Listed

Endorsement definitions: (1) “Recommended”: The outcome measure has been applied to PDD patients and has been found valid, reliable, and responsive in psychometric studies in studies of PDD or other dementias; (2) “Suggested”: The outcome measure has been applied to PDD patients and psychometric studies are promising (“moderate” to “high” parameters), but not yet complete in dementia populations and/or some psychometric properties are suboptimal (“low”); and (3) “Listed”: The outcome measure has been applied to PDD patients, but psychometric studies have demonstrated disappointing data (“low” parameters) and/or have not yet been performed in dementia populations.

QTCS, Quick Test of Cognitive Speed; VMI, Developmental Test of Visual‐Motor Integration; BTA, Brief Test of Attention; PDD, Parkinson's disease dementia; NE, Not established.