Table 3.
Primates-specific microRNAs
| Gene | Copies in Human | Target Genes (miRNAmap) | Description of target genes (miRNAmap) | Target Genes (microRNA) | Description of target genes (microRNA) | Location of miRNA |
|---|---|---|---|---|---|---|
| mir-550 | 3 | PRDM2 | PR domain zinc finger protein 2 | LGI1 | leucine-rich, glioma inactivated 1 (LGI1) | + Inside intron of gene ZNRF2 (zinc and ring finger 2) |
| + Inside intron of AVL9 homolog from S.cerevisiae | ||||||
| FUSIP1 | FUS-interacting serine-arginine-rich protein 1 | SHISA2 | Shisa homolog 2 (Xenopus laevis) | |||
| POU2F1 | POU class 2 homeobox 1 | |||||
| mir-556 | 1 | KIF1B | Kinesin-like protein KIF1B (Klp) | + Inside intron of gene NOS1AP (nitric oxide synthase 1 (neuronal) adaptor protein) | ||
| TARDBP | TAR DNA-binding protein 43 (TDP-43) | |||||
| LYPLA2 | Acyl-protein thioesterase 2 | |||||
| mir-573 | 1 | CPSF3L | Integrator complex subunit 11 | LARP1B | La ribonucleoprotein domain family, member 1B | +Intergenic |
| C10orf118 | Chromosome 10 open reading frame 118 | |||||
| SLC25A26 | Solute carrier family 25, member 26 | |||||
| CCDC62 | coiled-coil domain containing 62 | |||||
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6 sialyltransferase 3 | |||||
| mir-580 | 1 | PARK7 | Protein DJ-1 (Oncogene DJ1) (Parkinson disease protein 7) | ZBTB1 | Zinc finger and BTB domain containing 1 | +Inside intron of gene LMBR1D2 (LMBR1 domain containing 2) |
| ALPL | Alkaline phosphatase, tissue-nonspecific isozyme precursor | EPB41L2 | Erythrocyte membrane protein band 4.1-like 2 | |||
| MRPL42 | Mitochondrial ribosomal protein L42 | |||||
| PYROXD1 | Pyridine nucleotide-disulphide oxidoreductase domain 1 | |||||
| mir-581 | 1 | FRAP1 | FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR) | THAP1 | THAP domain containing, apoptosis associated protein 1 | +Inside intron of gene ARL15 (ADP-ribosylation factor-like 15) |
| RBM6 | RNA binding motif protein 6 | |||||
| MYO10 | myosin X | |||||
| CCDC66 | Coiled-coil domain containing 66 | |||||
| mir-583 | 1 | SPSB1 | SPRY domain-containing SOCS box protein 1 (SSB-1) | CCDC141 | Coiled-coil domain containing 141 | +Intergenic |
| SPEN | Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein). | ZNF512 | zinc finger protein 512 | |||
| CDC42 | Cell division control protein 42 homolog precursor (G25K GTP-binding protein). | WNK3 | WNK lysine deficient protein kinase 3 | |||
| mir-586 | 1 | ZUBR1 | retinoblastoma-associated factor 600 | FAM164A/ZC2HC1A | zinc finger, C2HC-type containing 1A | +Inside intron of gene SUPT3H (suppressor of Ty 3 homolog (S. cerevisiae)) |
| FAM76A | Protein FAM76A | MMP13 | Matrix metallopeptidase 13 (collagenase 3) | |||
| STX12 | Syntaxin-12 | ITPR1 | Inositol 1,4,5-trisphosphate receptor, type 1 | |||
| mir-597 | 1 | CCNL2 | Cyclin-L2 (Paneth cell-enhanced expression protein) | SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | +Inside intron of gene TNKS1 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase) |
| UBE4B | Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Homozygously deleted in neuroblastoma 1) | |||||
| mir-601 | 1 | PPP1R8 | Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) | PMCHL2 | pro-melanin-concentrating hormone-like 2, pseudogene (ncRNA) | +Inside intron of gene DENND1A (DENN/MADD domain containing 1A) |
| ZBTB8 | Zinc finger and BTB domain-containing protein 8 | |||||
| FHL3 | Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM- protein 2) (SLIM 2) | |||||
| mir-605 | 1 | TARDBP | TAR DNA-binding protein 43 (TDP-43) | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | +Inside intron of gene PRKG1 (protein kinase, cGMP-dependent, type I) |
| RPA2 | Replication protein A 32 kDa subunit (RP-A) (RF-A) (Replication factor-A protein 2) (p32) (p34) | SERTAD4 | SERTA domain containing 4 | |||
| TAF12 | Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15) | LUC7L3 | LUC7-like 3 (S. cerevisiae) | |||
| mir-624 | 1 | PANK4 | Pantothenate kinase 4 | NBEA | Neurobeachin | +Inside intron of gene STRN3 (striatin, calmodulin binding protein 3) |
| TARDBP | TAR DNA-binding protein 43 (TDP-43) | SS18 | Synovial sarcoma translocation, chromosome 18 | |||
| ARID1A | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) | PPP6R3 | Protein phosphatase 6, regulatory subunit 3 | |||
| mir-640 | 1 | KIF1B | Kinesin-like protein KIF1B (Klp) | ZDHHC17 | Zinc finger, DHHC-type containing 17 | +Inside intron of gene GATAD2A (GATA zinc finger domain containing 2A) |
| VPS13D | Vacuolar protein sorting-associated protein 13D | SLC30A5 | Solute carrier family 30 (zinc transporter), member 5 | |||
| KCTD18 | Potassium channel tetramerisation domain containing 18 | |||||
| mir-648 | 1 | RERE | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | HBP1 | HMG-box transcription factor 1 | +Intergenic |
| KIF1B | Kinesin-like protein KIF1B (Klp) | MOG | Myelin oligodendrocyte glycoprotein | |||
| mir-651 | 1 | RER1 | Protein RER1 | ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | +Intergenic |
| SPDYE8P | Speedy homolog E8 (Xenopus laevis) | |||||
| BMP2K | BMP2 inducible kinase | |||||
| mir-887 | 1 | P2RY12 | Purinergic receptor P2Y, G-protein coupled, 12 | +Inside intron of gene FBXL7 (F-box and leucine-rich repeat protein 7) |
The target genes predicted by miRNAmap2.0 and microRNA and their description are shown.